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Every story we pull is tagged to the disease it’s about — so you can filter to your condition and read only what matters.
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sepsis induced coagulopathy sic is it monolithic
Original title: “Sepsis induced coagulopathy (SIC): is it monolithic?”
consensus recommendations in the management of jaw gnathic osteosarcoma
Original title: “Consensus recommendations in the management of jaw (gnathic) osteosarcoma.”
mislocalization of tdp 43 to mitochondria impairs myotube maturation
Original title: “The Mislocalization of TDP-43 to Mitochondria Impairs Myotube Maturation.”
maternal and fetal outcomes in imiglucerase treated patients with gaucher disease real world evidence from the international collaborative gaucher group icgg gaucher registry pregnancy sub registry
Original title: “Maternal and Fetal Outcomes in Imiglucerase-Treated Patients With Gaucher Disease: Real-World Evidence From the International Collaborative Gaucher Group (ICGG) Gaucher Registry Pregnancy Sub-Registry.”
How to accelerate cures for genetic diseases using an artificial intelligence-enabled discovery engine to identify druggable nodes and develop clinical targets. Nature Medicine - How to accelerate cures for genetic diseases using an artificial intelligence-enabled discovery engine to identify druggable nodes and develop clinical targets. How to accelerate cures for genetic diseases using an artificial intelligence-enabled discovery engine to identify druggable nodes and develop clinical targets. ... Instant access to the full article PDF. ... Fig. 1: Model–perturb–predict. Kaufmann, P., Pariser, A. R. & Austin, C. Orphanet J. Rare Dis. We thank K. Liguori for expert assistance with graphic design. Our funding is through the Ladders to Cures Scientific Accelerator of the Broad Institute of MIT and Harvard. We thank all of the rare disease patient advocacy groups who have partnered with the Ladders to Cures Scientific Accelerator. Shaw, J.L., Greka, A. Clinically distinct genetic diseases converge on shared, druggable nodes. Nat Med (2026).
Original title: “Clinically distinct genetic diseases converge on shared, druggable nodes | Nature Medicine”
efficacy and safety of relacorilant for the treatment of patients with cushing s syndrome grace a multicentre phase 3 double blind placebo controlled randomised withdrawal study
Original title: “Efficacy and safety of relacorilant for the treatment of patients with Cushing's syndrome (GRACE): a multicentre, phase 3, double-blind, placebo-controlled, randomised-withdrawal study.”
Current antidepressant therapies predominately target symptom remission in major depressive disorder (MDD) but often overlook social dysfunction, which is a critical determinant of functional recovery. Individualized, accelerated continuous theta burst stimulation (cTBS) targeting the right ... Current antidepressant therapies predominately target symptom remission in major depressive disorder (MDD) but often overlook social dysfunction, which is a critical determinant of functional recovery. Individualized, accelerated continuous theta burst stimulation (cTBS) targeting the right dorsolateral prefrontal cortex (R.DLPFC) may offer a potential therapeutic approach for concurrently improving clinical and psychosocial outcomes in MDD. Neuropsychopharmacology - Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial Individualized, accelerated continuous theta burst stimulation (cTBS) targeting the right dorsolateral prefrontal cortex (R.DLPFC) may offer a potential therapeutic approach for concurrently improving clinical and psychosocial outcomes in MDD. In this randomized, double-blind, sham-controlled trial, 70 patients with MDD were randomly assigned to receive either active (n = 37) or sham (n = 33) accelerated cTBS for 2 weeks. The treatments targeted individualized R.DLPFC sites, which were identified by task-evoked brain activation during a social interactive task (Ultimatum Game, UG). The active group also demonstrated enhanced cooperation behavior (p = 0.002) and increased learning rates (89% HDI: [0.01, 0.21]). And the active group exhibited increased effective connectivity from the right insula to the R.DLPFC and stable effective connectivity from the anterior cingulate cortex (ACC) to the left insula after treatment, which was different from the sham group (Pp > 0.95). No severe adverse events occurred. Individualized, accelerated cTBS targeting task-evoked activation in the R.DLPFC safely and effectively improves clinical symptoms and social dysfunction in MDD. Altered effective connectivity among the DLPFC, insula and ACC may provide mechanistic insights into its therapeutic effects. Trial Registration: chictr.org.cn; ChiCTR2300068273.
Original title: “Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial | Neuropsychopharmacology”
kidney transplantation in advanced octogenarians the world s oldest kidney transplant recipient
Original title: “Kidney Transplantation in Advanced Octogenarians: The World's Oldest Kidney Transplant Recipient.”
comprehensive multimodal imaging of quadricuspid pulmonary valves morphology function and mid term prognosis
Original title: “Comprehensive multimodal imaging of quadricuspid pulmonary valves: morphology, function, and mid-term prognosis.”
persistent hiccups as an atypical sole manifestation of st segment elevation myocardial infarction an interesting case report
Original title: “Persistent Hiccups as an Atypical Sole Manifestation of ST-Segment Elevation Myocardial Infarction: An Interesting Case Report.”
extraneurological presentations of tick borne encephalitis virus a rare case of tbev associated myocarditis with fever and bicytopenia and a systematic literature review
Original title: “Extraneurological Presentations of Tick-Borne Encephalitis Virus: A Rare Case of TBEV-Associated Myocarditis With Fever and Bicytopenia and a Systematic Literature Review.”
cooperative role of cd81 with gpr56 and collagen iii in cortical formation
Original title: “Cooperative role of CD81 with GPR56 and collagen III in cortical formation.”
giant polycystic liver disease with thoracic involvement an anaesthesia and surgical challenge in liver transplantation
Original title: “Giant polycystic liver disease with thoracic involvement: an anaesthesia and surgical challenge in liver transplantation.”
emergence of a novel cefotaxime and ciprofloxacin resistant strain of serogroup y neisseria meningitidis sequence type 23 clonal complex in china
Original title: “Emergence of a novel cefotaxime- and ciprofloxacin-resistant strain of serogroup Y Neisseria meningitidis sequence type 23 clonal complex in China.”
lipids in kidney diseases from systemic imbalance to intrarenal alterations of cellular lipid metabolism in rare and common kidney diseases
Original title: “Lipids in kidney diseases: from systemic imbalance to intrarenal alterations of cellular lipid metabolism in rare and common kidney diseases.”
how to monitor disease progression in attr amyloid cardiomyopathy implications for clinical practice and trial design
Original title: “How to monitor disease progression in ATTR amyloid cardiomyopathy: Implications for clinical practice and trial design.”
evaluation of the impact of different notification methods for unvaccinated individuals in a acwy meningococcal vaccination campaign
Original title: “Evaluation of the impact of different notification methods for unvaccinated individuals in a ACWY meningococcal vaccination campaign.”
epstein barr virus positive diffuse large b cell lymphoma presenting as pyrexia of unknown origin complicated by paraneoplastic neurological syndrome
Original title: “Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma Presenting as Pyrexia of Unknown Origin Complicated by Paraneoplastic Neurological Syndrome.”
relentless placoid chorioretinitis associated with crohn s disease and secondary mewds a case report
Original title: “Relentless placoid chorioretinitis associated with Crohn's disease and secondary MEWDS: a case report.”
prospective observational study to assess the prognosis of patients with myeloproliferative neoplasms in japan mpn 15 results of baseline analysis
Original title: “Prospective observational study to assess the prognosis of patients with myeloproliferative neoplasms in Japan (MPN-15): results of baseline analysis.”