Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
Every story we pull is tagged to the disease it’s about — so you can filter to your condition and read only what matters.
20 earlier
efficacy of radiation therapy in 106 patients with extramammary paget disease a retrospective study
Original title: “Efficacy of Radiation Therapy in 106 Patients with Extramammary Paget Disease: A Retrospective Study.”
breast implant associated epstein barr virus positive diffuse large b cell lymphoma
Original title: “Breast Implant-Associated Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma.”
interpretable ensemble machine learning framework for cardiovascular disease prediction using emr data and large language models in ethiopia
Original title: “Interpretable ensemble machine learning framework for cardiovascular disease prediction using EMR data and large language models in Ethiopia.”
successful treatment of posttransplant refractory pure red cell aplasia following parvovirus b19 infection
Original title: “Successful Treatment of Posttransplant Refractory Pure Red Cell Aplasia Following Parvovirus B19 Infection.”
amyloidogenic phenotypical variation affects post transplant outcome of hereditary transthyretin amyloidosis a retrospective study
Original title: “Amyloidogenic phenotypical variation affects post-transplant outcome of hereditary transthyretin amyloidosis: a retrospective study.”
pictural guide to postmortem examination of elephants
Original title: “A pictural guide to postmortem examination of elephants.”
viral infection and brain inflammation with seizures in park7 deficiency
Original title: “Viral infection and brain inflammation with seizures in PARK7 deficiency.”
Real-world evidence complements RCTs, influencing trial planning and regulatory decisions, despite challenges like incomplete data and privacy concerns. Economic pressures in rare disease drug development lead to strategic reassessment, focusing on efficiency, technology, and alternative therapeutic areas.SHOW MORE · Generative AI adoption, regulatory scrutiny, DEI policy shifts, real-world evidence, and rare disease economics emerged as key themes across these most-read Applied Clinical ... Real-world evidence complements RCTs, influencing trial planning and regulatory decisions, despite challenges like incomplete data and privacy concerns. Economic pressures in rare disease drug development lead to strategic reassessment, focusing on efficiency, technology, and alternative therapeutic areas.SHOW MORE · Generative AI adoption, regulatory scrutiny, DEI policy shifts, real-world evidence, and rare disease economics emerged as key themes across these most-read Applied Clinical Trials articles shaping clinical research and drug development today. Rare disease drug development has expanded significantly since the Orphan Drug Act, but declining returns and rising costs are forcing sponsors to reassess their strategies. The article outlines clinical and commercial challenges, including longer and more complex trials, limited patient populations, ethical issues with control groups, and high manufacturing costs—particularly for gene therapies. While sponsors remain committed to addressing unmet needs, economic pressures are driving divestment, restructuring, and renewed focus on efficiency, technology-enabled development, and alternative therapeutic areas. Stay current in clinical research with Applied Clinical Trials, providing expert insights, regulatory updates, and practical strategies for successful clinical trial design and execution. Recent US executive orders banning DEI initiatives have created uncertainty across the clinical research ecosystem, particularly around diversity-focused recruitment and engagement efforts. The article examines potential consequences for sponsors, sites, patients, healthcare systems, and regulators, noting risks to trial representativeness, public trust, and R&D efficiency.
Original title: “Our Top 5 Most Read Articles in 2025 | Applied Clinical Trials Online”
do generalized epilepsies exhibit more attentional or executive disorders
Original title: “Do generalized epilepsies exhibit more attentional or executive disorders?”
occupational therapy intervention in a child with multicentric carpotarsal osteolysis case report
Original title: “Occupational therapy intervention in a child with multicentric carpotarsal osteolysis: Case report.”
proteome scale autoantibody profiling in psc associations with clinical phenotypes and evidence for neuroendocrine deregulations
Original title: “Proteome-scale autoantibody profiling in PSC: Associations with clinical phenotypes and evidence for neuroendocrine deregulations.”
rare variants in antisense long noncoding rna protein coding gene overlap regions contribute to obsessive compulsive disorder
Original title: “Rare Variants in Antisense Long Noncoding RNA-Protein-Coding Gene Overlap Regions Contribute to Obsessive-Compulsive Disorder.”
dapagliflozin in patients with ckd with fabry disease
Original title: “Dapagliflozin in Patients With CKD With Fabry Disease.”
on a quest for fingerprints of crystalglobulinemia on platelets and endothelium
Original title: “On a quest for fingerprints of crystalglobulinemia on platelets and endothelium.”
minimally invasive robotic surgery for left lower lobe arteriovenous malformation
Original title: “Minimally invasive robotic surgery for left lower lobe arteriovenous malformation.”
rare variant in triobp linked to occupational noise exposure in meniere disease
Original title: “A rare variant in TRIOBP linked to occupational noise exposure in Meniere disease.”
Abstention from drug use remains at historic high, NIH-supported survey finds.
Original title: “Reported use of most drugs remains low among U.S. teens”
rare tracheal schwannoma in a child successful resection via cervical incision
Original title: “Rare tracheal schwannoma in a child: successful resection via cervical incision.”
NIH clinical trial shows promise for people with treatment-limited, life-threatening disorder.
Original title: “Expanded umbilical cord blood transplant achieves 94% survival in severe aplastic anemia patients”
Sherlock-Lung study researchers use large-scale, multi-omics analysis to identify biomarker of aggressive lung tumors.
Original title: “NIH-led study reveals role of mobile DNA elements in lung cancer progression”