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response to comment on fibrinogen promotes acute myelogenous leukemia progression via mir 486 gpr153 axis
Original title: “Response to Comment on: "Fibrinogen promotes acute myelogenous leukemia progression via miR-486/GPR153 axis".”
epidemiology of progressive cerebellar ataxia in south yorkshire uk
Original title: “Epidemiology of progressive cerebellar ataxia in South Yorkshire, UK.”
rilzabrutinib an oral bruton tyrosine kinase inhibitor in patients with warm autoimmune haemolytic anaemia a prospective single arm multicentre phase 2b safety and clinical activity study lumina 2
Original title: “Rilzabrutinib, an oral Bruton tyrosine kinase inhibitor, in patients with warm autoimmune haemolytic anaemia: a prospective, single-arm, multicentre, phase 2b safety and clinical activity study (LUMINA 2).”
novel borcs5 loss of function variant in a patient with a rare neurodevelopmental disorder
Original title: “A Novel BORCS5 Loss-Of-Function Variant in a Patient With a Rare Neurodevelopmental Disorder.”
cerebral schistosoma japonicum infection confirmed by histopathology and pcr diagnostic and therapeutic challenges in multiple parasitic coinfections
Original title: “Cerebral Schistosoma japonicum infection confirmed by histopathology and PCR: Diagnostic and therapeutic challenges in multiple parasitic coinfections.”
genetic testing in clinical immunology what to know and how to do it
Original title: “Genetic Testing in Clinical Immunology: What to Know and How to Do It.”
antimicrobial resistance profiles and genomic diversity of vaginal prevotella bivia isolates from south african women including the first report of nimk in south african vaginal p bivia isolates
Original title: “Antimicrobial resistance profiles and genomic diversity of vaginal Prevotella bivia isolates from South African women, including the first report of nimK in South African vaginal P. bivia isolates.”
The application of chimeric antigen receptor T (CAR-T) cells in hematologic malignancies has driven significant advancements in this form of immunotherapy. The therapeutic strategy of CAR-T cells targeting specific cell populations has opened new avenues for treating non-oncological diseases, ... The application of chimeric antigen receptor T (CAR-T) cells in hematologic malignancies has driven significant advancements in this form of immunotherapy. The therapeutic strategy of CAR-T cells targeting specific cell populations has opened new avenues for treating non-oncological diseases, such as autoimmune diseases, aging-related conditions, and infections. Signal Transduction and Targeted Therapy - Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases With this background, this article aims to introduce the latest research, mechanisms, and applications of CAR-T cell therapy in non-oncological diseases, summarize the pathogenesis of related disorders, and discuss the advantages, challenges, and future prospects of CAR-T cell therapy. ... Discover the latest articles and news in related subjects. ... Chimeric Antigen Receptor T (CAR-T) cells are genetically engineered T lymphocytes expressing synthetic transmembrane receptors that confer antigen-specific targeting capabilities. CAR-T cell therapy represents a transformative approach for immune reconstitution in autoimmune diseases through two complementary mechanisms: targeted depletion of autoreactive lymphocytes and restoration of regulatory functions. The pathogenesis of autoimmune disorders stems from complex interactions between genetic predisposition and environmental triggers that disrupt immune tolerance.110,111,112,113 This breakdown manifests most prominently as aberrant activation of B and T lymphocytes against self-antigens, resulting in pathogenic autoantibody production.
Original title: “Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases | Signal Transduction and Targeted Therapy”
large osseous choristoma of the tongue base a case report and literature review
Original title: “Large Osseous Choristoma of the Tongue Base: A Case Report and Literature Review.”
late awakening delayed functional transformation of a silent corticotroph adenoma into cushing disease
Original title: “A late awakening: delayed functional transformation of a silent corticotroph adenoma into Cushing disease.”
progressive anterior opercular syndrome foix chavany marie syndrome in neurodegenerative disease a case series
Original title: “Progressive anterior opercular syndrome (Foix-Chavany-Marie syndrome) in neurodegenerative disease: a case series.”
genomic data governance challenges between research and clinical care a scoping review
Original title: “Genomic Data Governance Challenges Between Research and Clinical Care: A Scoping Review.”
long term outcomes of ewing sarcoma of the foot and ankle
Original title: “Long-Term Outcomes of Ewing Sarcoma of the Foot and Ankle.”
well differentiated smarcb1 deficient pancreatic malignancy with indolent liver metastases
Original title: “Well-differentiated SMARCB1-deficient Pancreatic Malignancy With Indolent Liver Metastases.”
primary renal ewing sarcoma with extensive metastatic disease at diagnosis a case report and literature review
Original title: “Primary renal Ewing sarcoma with extensive metastatic disease at diagnosis: A case report and literature review.”
from genomics to precision cardiology a comprehensive review of clinical applications and challenges in cardiovascular diseases
Original title: “From Genomics to Precision Cardiology: A Comprehensive Review of Clinical Applications and Challenges in Cardiovascular Diseases.”
sustained low disease activity during long term mepolizumab treatment in fip1l1 pdgfra negative hypereosinophilic syndrome a multicenter real world study
Original title: “Sustained low disease activity during long-term mepolizumab treatment in FIP1L1::PDGFRA-negative hypereosinophilic syndrome: a multicenter real-world study.”
thalassemia as a progressive disease age related morbidity in the de light study
Original title: “β-thalassemia as a progressive disease: age-related morbidity in the de-LIGHT study.”
evaluating potential sources of bias in linear growth rate analysis of renal tumors case study in von hippel lindau disease
Original title: “Evaluating potential sources of bias in linear growth rate analysis of renal tumors: case study in Von-Hippel Lindau disease.”
small populations big impact leveraging rare disease gene therapies to benefit millions
Original title: “Small populations, big impact: leveraging rare disease gene therapies to benefit millions.”