Acitretin/Etretinate embryopathy is a disorder that occurs when a pregnant person is exposed to the medications acitretin or etretinate during the first trimester. These drugs are known to be teratogenic, meaning they can cause birth defects. The condition is associated with a risk of fetal malformations of about 20%, affecting different parts of the body. The reported malformations include anomalies in the central nervous system, facial structures, ears, thymic tissue, heart, and limbs. This condition is rare and is directly linked to the use of these medication agents during early pregnancy.

People with this condition may show signs of malformations that can affect the brain, face, ears, thymus, heart, and limbs. The malformations vary, and not all affected individuals may have the same features.

This condition is caused by the use of the medications acitretin or etretinate during the first trimester of pregnancy. These drugs act as teratogens, which means they can interfere with fetal development and cause birth defects.