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Acquired von Willebrand syndrome (AVWS) is a bleeding disorder marked by the same biological anomalies as those seen in hereditary von Willebrand disease (VWD) but which occurs in association with another underlying pathology, generally in elderly patients without any personal or family history of bleeding anomalies.
Features include common findings: Reduced factor VIII activity, Hematological neoplasm, Prolonged prothrombin time, and Reduced von Willebrand factor activity and others; and sometimes findings: Menorrhagia, Epistaxis, Gastrointestinal angiodysplasia, and Blood in the urine (hematuria) and others. 27 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Heart and blood vessels | 4 | Aortic valve stenosis, Mitral regurgitation, Aortic regurgitation |
Biomarker and diagnostic research for acquired von willebrand syndrome has been reported in the published literature.
Phenotype severity distribution: 6 common features.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
3 clinical trials registered, 1 recruiting. Interventions under study include other interventions and procedural interventions. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.
130 publications have been identified in PubMed for acquired von willebrand syndrome. Research spans Case Report / Case Series (38%), Review / Meta-Analysis (27%), and Epidemiology / Natural History (12%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 50 |
Data assembled from 5 of 12 sources · Last updated Oct 4, 2026, 6:18 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about acquired von willebrand syndrome
Blood and immune system | 4 | Normocytic anemia, Pale red blood cells (hypochromic anemia), Persistent bleeding after trauma |
Digestive system | 2 | Gastrointestinal angiodysplasia, Gastrointestinal hemorrhage |
Kidneys and urinary system | 1 | Blood in the urine (hematuria) |
Skin | 1 | Subcutaneous hemorrhage |
Bones and joints | 1 | Joint hemorrhage |
Research summaries | 35 | 27% |
Disease patterns and progression | 16 | 12% |
Other research | 7 | 5% |
Testing and diagnosis research | 7 | 5% |
Laboratory research | 7 | 5% |
Clinical study results | 5 | 4% |
New treatment approaches | 3 | 2% |
Gupta Y (2026). [PMID: 41623372](https://pubmed.ncbi.nlm.nih.gov/41623372/). *Health science reports*. [Gene Therapy / Novel Therapeutics]
Napoles RA (2026). [PMID: 42104596](https://pubmed.ncbi.nlm.nih.gov/42104596/). *Am J Case Rep*. [Case Report / Case Series]
Fuchs TK (2026). [PMID: 42046585](https://pubmed.ncbi.nlm.nih.gov/42046585/). *Cureus*. [Other]
Passaniti G (2026). [PMID: 41949248](https://pubmed.ncbi.nlm.nih.gov/41949248/). *JACC. Asia*. [Basic Science / Preclinical]
Kumar V (2026). [PMID: 41751340](https://pubmed.ncbi.nlm.nih.gov/41751340/). *Biomedicines*. [Review / Meta-Analysis]
Thomas M (2026). [PMID: 41692094](https://pubmed.ncbi.nlm.nih.gov/41692094/). *J Thromb Haemost*. [Case Report / Case Series]
Dong X (2026). [PMID: 41565246](https://pubmed.ncbi.nlm.nih.gov/41565246/). *Expert Opin Drug Saf*. [Epidemiology / Natural History]
Roberts TR (2026). [PMID: 41692097](https://pubmed.ncbi.nlm.nih.gov/41692097/). *J Thromb Haemost*. [Basic Science / Preclinical]
Morelli F (2026). [PMID: 41831041](https://pubmed.ncbi.nlm.nih.gov/41831041/). *Ann Hematol*. [Clinical Trial Publication]
Nuñez Zuno JA (2026). [PMID: 29261870](https://pubmed.ncbi.nlm.nih.gov/29261870/). *Unknown Journal*. [Review / Meta-Analysis]
AI-curated news mentioning acquired von willebrand syndrome
Updated Jun 10, 2026
A recent study provides a comprehensive clinical and laboratory characterization of acquired von Willebrand syndrome, enhancing understanding of its pathophysiology. This research may inform future diagnostic and therapeutic strategies for affected patients.