Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

active tuberculosis - Clinical Profile, Treatments & Trials | Kisho | Kisho

Rare Disease

active tuberculosis

MONDO:0100481

Also known as:active TB

Find Clinical TrialsTrials

Overview

Tuberculosis caused by primary infection of or reactivation of latent Mycobacterium tuberculosis. Active tuberculosis characterized by clinical manifestation and active symptoms compatible with tuberculosis, and is distinct from latent tuberculosis infection that occurs without signs or symptoms of active disease.

Treatments1 FDA approved

Clinical Trials123 registered · 57 recruiting

Diagnosis

Biomarker and diagnostic research for active tuberculosis has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

1 FDA-approved treatment is available for active tuberculosis, including BEDAQUILINE FUMARATE (SIRTURO, approved 2012). An additional 4 compounds hold orphan drug designation.

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

123 clinical trials registered, 57 recruiting. Interventions under study include other interventions, drug therapy, biologic therapy, and medical devices. Pipeline includes 3 PHASE4, 12 PHASE3, 10 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT05842161](https://clinicaltrials.gov/study/NCT05842161)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 3:00 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→What are the benefits and potential side effects of SIRTURO for managing active tuberculosis?
→Are any of the 123 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Brand Name	Generic Name	Sponsor	Designated	Exclusivity End	Designation Status
tubimod	tubimod	Immunitor, Inc.	2017	—	Designated
5-{[(3R,4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidin-4-yl]methoxy}-8-fluoro-3,4-dihydroquinolin-2(1H)-one	5-{[(3R,4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidin-4-yl]methoxy}-8-fluoro-3,4-dihydroquinolin-2(1H)-one	Otsuka Pharmaceutical Company, Ltd	2016	—	Designated
clofazimine	clofazimine	Novartis Pharmaceuticals Corp.	2014	—	Withdrawn
heat killed Mycobacterium w immunomodulator	heat killed Mycobacterium w immunomodulator	Cadila Pharmaceuticals Limited, Inc.	2004	—	Designated

Research Type	Count	% of Total
Disease patterns and progression	105	27%
Testing and diagnosis research	90	23%
Research summaries	84	22%
Laboratory research	63	16%
Clinical study results	19	5%
Patient case studies	12	3%
New treatment approaches	7	2%
Other research	5	1%

Kisho

active tuberculosis

Overview

Diagnosis

Treatment

Approved Therapies

Research Landscape

Medical References

Questions for Your Care Team

Questions for Your Care Team

Orphan Drug Designations

Clinical Trials

Recent Publications

active tuberculosis

Overview

Diagnosis

Treatment

Approved Therapies

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Orphan Drug Designations

Clinical Trials

Recent Publications