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An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells. (WHO, 2001)
Biomarker and diagnostic research for acute leukemia of ambiguous lineage has been reported in the published literature.
61 clinical trials registered, 37 recruiting. Interventions under study include drug therapy, procedural interventions, biologic therapy, and other interventions. Pipeline includes 1 PHASE4, 7 PHASE3, 23 PHASE2. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06756152](https://clinicaltrials.gov/study/NCT06756152) |
Data assembled from 4 of 12 sources · Last updated Oct 3, 2026, 8:13 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about acute leukemia of ambiguous lineage
Preventing of GVHD with Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Ruxolitinib At Children and Young Adults with Hemoblastosis |
PHASE2 |
Federal Research Institute of Pediatric Hematology, Oncology and Immunology |
RECRUITING |
[NCT07222579](https://clinicaltrials.gov/study/NCT07222579) | Subcutaneous Blinatumomab for Treatment of Adult Patients With CD19-Positive Mixed Phenotype Acute Leukemia (MPAL) | PHASE2 | West Virginia University | RECRUITING |
[NCT06928662](https://clinicaltrials.gov/study/NCT06928662) | Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse | PHASE1 | Fred Hutchinson Cancer Center | RECRUITING |
[NCT06508099](https://clinicaltrials.gov/study/NCT06508099) | Vitamin A and D Supplementation in Allogeneic HCT | PHASE2 | St. Petersburg State Pavlov Medical University | RECRUITING |
[NCT06317662](https://clinicaltrials.gov/study/NCT06317662) | Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia | PHASE2 | National Cancer Institute (NCI) | RECRUITING |
29 publications have been identified in PubMed for acute leukemia of ambiguous lineage. Research spans Case Report / Case Series (31%), Review / Meta-Analysis (24%), and Gene Therapy / Novel Therapeutics (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 9 | 31% |
Research summaries | 7 | 24% |
New treatment approaches | 4 | 14% |
Testing and diagnosis research | 3 | 10% |
Clinical study results | 3 | 10% |
Laboratory research | 3 | 10% |
Wang SA (2026). [PMID: 40905082](https://pubmed.ncbi.nlm.nih.gov/40905082/). *Haematologica*. [Gene Therapy / Novel Therapeutics]
Sherban A (2026). [PMID: 41063702](https://pubmed.ncbi.nlm.nih.gov/41063702/). *Haematologica*. [Review / Meta-Analysis]
Li Y (2026). [PMID: 41540127](https://pubmed.ncbi.nlm.nih.gov/41540127/). *Annals of hematology*. [Clinical Trial Publication]
Wang WJ (2026). [PMID: 41195731](https://pubmed.ncbi.nlm.nih.gov/41195731/). *American journal of hematology*. [Gene Therapy / Novel Therapeutics]
Stokol T (2026). [PMID: 41546140](https://pubmed.ncbi.nlm.nih.gov/41546140/). *Veterinary clinical pathology*. [Diagnostic / Biomarker]
Biswas D (2026). [PMID: 41717956](https://pubmed.ncbi.nlm.nih.gov/41717956/). *Indian journal of pathology & microbiology*. [Diagnostic / Biomarker]
Saft L (2026). [PMID: 41948832](https://pubmed.ncbi.nlm.nih.gov/41948832/). *American journal of clinical pathology*. [Review / Meta-Analysis]
Zhang A (2026). [PMID: 41988760](https://pubmed.ncbi.nlm.nih.gov/41988760/). *Haematologica*. [Basic Science / Preclinical]
Shibeeb S (2026). [PMID: 41975767](https://pubmed.ncbi.nlm.nih.gov/41975767/). *Diagnostics (Basel)*. [Review / Meta-Analysis]
Fei F (2026). [PMID: 42248548](https://pubmed.ncbi.nlm.nih.gov/42248548/). *J Mol Diagn*. [Basic Science / Preclinical]