Acute myeloid leukemia, t(10;11)(p11.2;q23) is a rare subtype of acute myeloid leukemia. It is defined by a specific chromosomal change known as a translocation. In this case, a part of chromosome 10 (at p11.2) exchanges genetic material with a part of chromosome 11 (at q23). This rearrangement can lead to unusual gene fusions that affect the behavior of blood cells. This condition is linked to fusions involving genes such as KMT2A (MLL) and ABI1. Because these gene fusions alter normal cell growth, the bone marrow produces cells that do not develop correctly. Although this chromosomal abnormality is only found in a subset of acute myeloid leukemia cases, it highlights a distinct way in which the disease can occur. Ongoing research continues to explore how these gene changes impact cell function and disease development.

Information about symptoms is currently limited for this condition.

This condition is directly related to a chromosomal abnormality, specifically the t(10;11)(p11.2;q23) translocation. The exchange of genetic material between chromosomes 10 and 11 can lead to the fusion of genes, such as KMT2A (MLL) and ABI1. These gene fusions are believed to trigger abnormal growth and development of blood cells, contributing to the leukemia. Information about additional risk factors or causes is currently limited for this condition.