Acute myeloid leukemia, t(8;21)(q22; q22.1) is a type of blood cancer where abnormal white blood cells called myeloblasts grow rapidly. In this condition, a specific genetic change known as the t(8;21)(q22;q22) translocation occurs. This results in the production of an abnormal protein called RUNX1-RUNX1T1, which is involved in the development of the cancer. The disease is characterized by the appearance of large myeloblasts in the bone marrow and peripheral blood. These cells have abundant basophilic cytoplasm and often contain azurophilic granules. This set of features helps in the understanding and identification of the condition.

Information about symptoms is currently limited for this condition.

The condition is linked with a specific genetic change where parts of chromosomes 8 and 21 exchange segments. This leads to the formation of the RUNX1-RUNX1T1 fusion protein, which plays a role in the abnormal growth of blood cells. Information about additional causes or risk factors is currently limited for this condition.