Acute myeloid leukemia with 11q23 abnormalities is a type of blood cancer defined by a specific genetic change called t(9;11)(p22.3;q23.3), which leads to the production of the MLLT3-KMT2A fusion protein. This change affects how cells grow and develop and is usually seen in cancers of the blood and bone marrow. This type of leukemia most often shows features where the cancer cells resemble monocytes, a type of white blood cell, and it is more commonly diagnosed in children than in adults. Some people with this condition may also experience issues such as disseminated intravascular coagulation, a disorder that affects blood clotting.

People with this condition may experience symptoms related the blood and bone marrow. For example, patients may present with disseminated intravascular coagulation, a serious condition that disrupts normal blood clotting. More detailed symptom information is not provided in the available sources.

This condition is caused by a genetic change, specifically the rearrangement involving t(9;11)(p22.3;q23.3), leading to the expression of the MLLT3-KMT2A fusion protein. This abnormality affects normal blood cell development and is a key factor in this type of leukemia. The genetic change is inherent to the cancer cells and is most commonly seen in children.