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A rare acute leukemia of ambiguous lineage in which the blasts do not express markers specific to myeloid or lymphoid lineage.
Biomarker and diagnostic research for acute undifferentiated leukemia has been reported in the published literature.
13 clinical trials registered, 7 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 1 PHASE2, 8 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05476770](https://clinicaltrials.gov/study/NCT05476770) |
Data assembled from 4 of 12 sources · Last updated Oct 4, 2026, 3:02 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about acute undifferentiated leukemia
Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies |
PHASE1 |
Therapeutic Advances in Childhood Leukemia Consortium |
RECRUITING |
[NCT04375631](https://clinicaltrials.gov/study/NCT04375631) | CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia | PHASE1 | Fred Hutchinson Cancer Center | RECRUITING |
[NCT05322850](https://clinicaltrials.gov/study/NCT05322850) | Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT) | PHASE1 | University of Florida | RECRUITING |
[NCT01137643](https://clinicaltrials.gov/study/NCT01137643) | Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer | — | UNC Lineberger Comprehensive Cancer Center | RECRUITING |
[NCT06928662](https://clinicaltrials.gov/study/NCT06928662) | Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse | PHASE1 | Fred Hutchinson Cancer Center | RECRUITING |
111 publications have been identified in PubMed for acute undifferentiated leukemia. Research spans Basic Science / Preclinical (52%), Gene Therapy / Novel Therapeutics (15%), and Case Report / Case Series (8%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 58 | 52% |
New treatment approaches | 17 | 15% |
Patient case studies | 9 | 8% |
Testing and diagnosis research | 8 | 7% |
Research summaries | 7 | 6% |
Disease patterns and progression | 6 | 5% |
Clinical study results | 4 | 4% |
Other research | 2 | 2% |
Shi H (2026). [PMID: 41643149](https://pubmed.ncbi.nlm.nih.gov/41643149/). *ACS sensors*. [Diagnostic / Biomarker]
Li N (2026). [PMID: 41547479](https://pubmed.ncbi.nlm.nih.gov/41547479/). *The American journal of pathology*. [Basic Science / Preclinical]
Ji R (2026). [PMID: 42165443](https://pubmed.ncbi.nlm.nih.gov/42165443/). *Chin Med J (Engl)*. [Basic Science / Preclinical]
Siddon AJ (2026). [PMID: 42154861](https://pubmed.ncbi.nlm.nih.gov/42154861/). *Am J Clin Pathol*. [Review / Meta-Analysis]
Li X (2026). [PMID: 41850237](https://pubmed.ncbi.nlm.nih.gov/41850237/). *Cell Rep Med*. [Basic Science / Preclinical]
Zhang T (2026). [PMID: 42107071](https://pubmed.ncbi.nlm.nih.gov/42107071/). *Adv Sci (Weinh)*. [Basic Science / Preclinical]
Wang T (2026). [PMID: 42184909](https://pubmed.ncbi.nlm.nih.gov/42184909/). *J Ethnopharmacol*. [Basic Science / Preclinical]
Dias CK (2026). [PMID: 42122195](https://pubmed.ncbi.nlm.nih.gov/42122195/). *Cancers (Basel)*. [Epidemiology / Natural History]
Zhao X (2026). [PMID: 42131081](https://pubmed.ncbi.nlm.nih.gov/42131081/). *EXO*. [Other]
Köhnke T (2026). [PMID: 41263425](https://pubmed.ncbi.nlm.nih.gov/41263425/). *Cancer discovery*. [Epidemiology / Natural History]