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An autoimmune disease of the pituitary gland which can present with varying degrees of pituitary hormonal impairment and/or with symptoms related to pituitary enlargement. It predominantly affects young women in pregnancy or the peripartum period.
Features include very common findings: Panhypopituitarism; and common findings: Amenorrhea, Blurred vision, Impotence, and Increased circulating prolactin concentration and others. 32 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Hormones | 7 | Amenorrhea, Decreased circulating cortisol level, Secondary growth hormone deficiency |
Biomarker and diagnostic research for adenohypophysitis has been reported in the published literature.
Phenotype severity distribution: 1 very common feature, 23 common features.
No clinical trials have been registered for adenohypophysitis.
45 publications have been identified in PubMed for adenohypophysitis. Research spans Case Report / Case Series (49%), Review / Meta-Analysis (20%), and Epidemiology / Natural History (11%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 22 | 49% |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 8:40 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about adenohypophysitis
Lab test results |
3 |
Increased circulating prolactin concentration, Decreased circulating cortisol level, Antinuclear antibody positivity |
Eyes | 2 | Blurred vision, Diplopia |
Brain and nerves | 2 | Headache, Chronic lymphocytic meningitis |
Blood and immune system | 1 | Normochromic anemia |
Digestive system | 1 | Nausea |
Growth and development | 1 | Secondary growth hormone deficiency |
Ears | 1 | Inner ear hearing loss (sensorineural hearing impairment) |
9 |
20% |
Disease patterns and progression | 5 | 11% |
Clinical study results | 4 | 9% |
Laboratory research | 4 | 9% |
Testing and diagnosis research | 1 | 2% |
Pedersen S (2026). [PMID: 41713079](https://pubmed.ncbi.nlm.nih.gov/41713079/). *European journal of cancer (Oxford, England : 1990)*. [Clinical Trial Publication]
Maymin A (2026). [PMID: 41756559](https://pubmed.ncbi.nlm.nih.gov/41756559/). *Radiology case reports*. [Case Report / Case Series]
Fukuta T (2026). [PMID: 41509149](https://pubmed.ncbi.nlm.nih.gov/41509149/). *Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology*. [Case Report / Case Series]
Angelousi A (2026). [PMID: 41243162](https://pubmed.ncbi.nlm.nih.gov/41243162/). *Journal of neuroendocrinology*. [Basic Science / Preclinical]
Sharma A (2026). [PMID: 41553166](https://pubmed.ncbi.nlm.nih.gov/41553166/). *Indian journal of pathology & microbiology*. [Review / Meta-Analysis]
Asadikaram M (2025). [PMID: 41476991](https://pubmed.ncbi.nlm.nih.gov/41476991/). *International journal of endocrinology*. [Review / Meta-Analysis]
Piechota M (2025). [PMID: 40346507](https://pubmed.ncbi.nlm.nih.gov/40346507/). *BMC genomics*. [Basic Science / Preclinical]
Rajan R (2025). [PMID: 40917318](https://pubmed.ncbi.nlm.nih.gov/40917318/). *Indian journal of endocrinology and metabolism*. [Review / Meta-Analysis]
Chamorro-Pareja N (2025). [PMID: 40001294](https://pubmed.ncbi.nlm.nih.gov/40001294/). *The Journal of clinical endocrinology and metabolism*. [Epidemiology / Natural History]
Miquel L (2025). [PMID: 39312231](https://pubmed.ncbi.nlm.nih.gov/39312231/). *The Journal of clinical endocrinology and metabolism*. [Epidemiology / Natural History]