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adiposis dolorosa - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

adiposis dolorosa

MONDO:0007070

Also known as:AdiposalgiaDercum diseaseDercum's Disease

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Overview

Adiposis dolorosa or Dercum's disease is characterized by the development of multiple, painful, subcutaneous lipomas in association with obesity, asthenia and fatigue, and range of mental disturbances including instability, depression, confusion, dementia and epilepsy.

GeneticsAutosomal dominant

TreatmentsNo approved treatments · 1 in pipeline

Clinical Trials2 registered

Patient Orgs1 organizations · Fat Disorders Resource Society

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Fatigue, Arthralgia, Depression, and Anxiety and others; and common findings: Abdominal distention, Chronic pain, Painful subcutaneous lipomas, and Subcutaneous lipoma and others. 40 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	11	Chronic pain, Fatigue, Depression

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for adiposis dolorosa. An additional 1 compound holds orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for adiposis dolorosa, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for adiposis dolorosa. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Prognosis

Phenotype severity distribution: 7 very common features, 13 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered. Interventions under study include drug therapy. Pipeline includes 1 PHASE2. Research is sponsored by a mix of industry and academic institutions.

14 publications have been identified in PubMed for adiposis dolorosa. Research spans Case Report / Case Series (36%), Other (14%), and Review / Meta-Analysis (14%).

Research Type	Count	% of Total
Patient case studies	5	36%

Data assembled from 7 of 12 sources · Last updated Sep 19, 2026, 12:49 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

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Fat Disorders Resource Society

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Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.

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Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:103200

Orphanet

European rare disease database

Orphanet:36397

GARD

Genetic and Rare Diseases Info Center

GARD:5750

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→What is the current development status of 5-(3,6-dibromo-9H-carbazol-9-yl)-N,N,N-trimethylpentan-1-aminium chloride, and when might it become available?
→Are there specialists or centers of excellence for this condition in my area?
→How can I connect with Fat Disorders Resource Society and other patient organizations for support?

← Back to All Diseases

Kisho

adiposis dolorosa

Overview

Clinical Presentation

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Clinical Trials

Recent Publications

adiposis dolorosa

Overview

Clinical Presentation

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Clinical Trials

Recent Publications