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An adult form of the peroxisomal disease X-linked adrenoleukodystrophy (X-ALD), characterized by spastic paraparesia and often associated with peripheral adrenal insufficiency in males. Both males and females can be affected with AMN.
Biomarker and diagnostic research for adrenomyeloneuropathy has been reported in the published literature.
5 clinical trials registered, 4 recruiting. Interventions under study include other interventions, drug therapy, and procedural interventions. Pipeline includes 1 PHASE2, 2 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03047369](https://clinicaltrials.gov/study/NCT03047369) |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:53 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about adrenomyeloneuropathy
The Myelin Disorders Biorepository Project |
— |
Children's Hospital of Philadelphia |
RECRUITING |
[NCT04925349](https://clinicaltrials.gov/study/NCT04925349) | Modeling Macrophages Activation Pattern in X-linked Adrenoleukodystrophy, Metachromatic Leukodystrophy and Adult Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia | — | Assistance Publique - Hôpitaux de Paris | RECRUITING |
[NCT06796920](https://clinicaltrials.gov/study/NCT06796920) | Epidural Spinal Cord Stimulation for Lower-limb Impairment in Adrenomyeloneuropathy | NA | Third Military Medical University | RECRUITING |
[NCT06513533](https://clinicaltrials.gov/study/NCT06513533) | Dimethyl Fumarate in Adrenomyeloneuropathy | PHASE2 | Pujol, Aurora, M.D. | ACTIVE_NOT_RECRUITING |
[NCT05443906](https://clinicaltrials.gov/study/NCT05443906) | Home Exercise for Individuals With Neurodegenerative Disease | NA | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | RECRUITING |
39 publications have been identified in PubMed for adrenomyeloneuropathy. Research spans Case Report / Case Series (33%), Epidemiology / Natural History (26%), and Basic Science / Preclinical (15%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 13 | 33% |
Disease patterns and progression | 10 | 26% |
Laboratory research | 6 | 15% |
New treatment approaches | 4 | 10% |
Testing and diagnosis research | 3 | 8% |
Research summaries | 3 | 8% |
Fine AS (2026). [PMID: 41508113](https://pubmed.ncbi.nlm.nih.gov/41508113/). *Orphanet journal of rare diseases*. [Epidemiology / Natural History]
Kloss A (2026). [PMID: 42036046](https://pubmed.ncbi.nlm.nih.gov/42036046/). *J Biol Chem*. [Diagnostic / Biomarker]
Holley S (2026). [PMID: 42103229](https://pubmed.ncbi.nlm.nih.gov/42103229/). *J Biol Chem*. [Gene Therapy / Novel Therapeutics]
Chang MC (2026). [PMID: 41871978](https://pubmed.ncbi.nlm.nih.gov/41871978/). *The Journal of international medical research*. [Case Report / Case Series]
Nakamura Y (2026). [PMID: 42021042](https://pubmed.ncbi.nlm.nih.gov/42021042/). *Intern Med*. [Case Report / Case Series]
Kessler C (2026). [PMID: 40961460](https://pubmed.ncbi.nlm.nih.gov/40961460/). *Amyotrophic lateral sclerosis & frontotemporal degeneration*. [Case Report / Case Series]
Benzoni C (2026). [PMID: 41667276](https://pubmed.ncbi.nlm.nih.gov/41667276/). *Journal of neurology, neurosurgery, and psychiatry*. [Case Report / Case Series]
Lam J (2026). [PMID: 41779991](https://pubmed.ncbi.nlm.nih.gov/41779991/). *Pain medicine case reports*. [Case Report / Case Series]
Li C (2025). [PMID: 40400408](https://pubmed.ncbi.nlm.nih.gov/40400408/). *British journal of pharmacology*. [Case Report / Case Series]
Engelen M (2025). [PMID: 39928328](https://pubmed.ncbi.nlm.nih.gov/39928328/). *JAMA pediatrics*. [Epidemiology / Natural History]