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hereditary motor and sensory neuropathy (HMSN) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hereditary motor and sensory neuropathy

MONDO:0015358

Also known as:HMSN

Overview

A group of slowly progressive inherited disorders affecting motor and sensory peripheral nerves. Subtypes include HMSNs I-VII. HMSN I and II both refer to CHARCOT-MARIE-Tooth DISEASE. HMSN III refers to hypertrophic neuropathy of infancy. HMSN IV refers to REFSUM DISEASE. HMSN V refers to a condition marked by a hereditary motor and sensory neuropathy associated with spastic paraplegia (see SPASTIC PARAPLEGIA, HEREDITARY). HMSN VI refers to HMSN associated with an inherited optic atrophy (OPTIC ATROPHIES, HEREDITARY), and HMSN VII refers to HMSN associated with retinitis pigmentosa. (From Adams et al., Principles of Neurology, 6th ed, p1343)

Diagnosis

Biomarker and diagnostic research for hereditary motor and sensory neuropathy has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hereditary motor and sensory neuropathy.

30 publications have been identified in PubMed for hereditary motor and sensory neuropathy. Research spans Basic Science / Preclinical (30%), Review / Meta-Analysis (27%), and Case Report / Case Series (23%).

Research Type	Count	% of Total
Laboratory research	9	30%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:42 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:140450

GARD

Genetic and Rare Diseases Info Center

GARD:12685

Questions for Your Care Team

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hereditary motor and sensory neuropathy

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications