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A malignant mesenchymal neoplasm composed of fibroblasts. It is characterized by collagen production and a herringbone architectural pattern. It is more commonly seen in middle-aged and older adults. It usually affects the deep soft tissues of extremities, trunk, head and neck. Adult fibrosarcomas may recur and metastasize to the lungs and bones.
Biomarker and diagnostic research for adult fibrosarcoma has been reported in the published literature.
22 clinical trials registered, 12 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 1 PHASE3, 11 PHASE2, 6 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03967834](https://clinicaltrials.gov/study/NCT03967834) |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 11:35 PM UTC
Common questions about adult fibrosarcoma
Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group |
NA |
Institut Claudius Regaud |
RECRUITING |
[NCT06277154](https://clinicaltrials.gov/study/NCT06277154) | MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma | PHASE2 | HRYZ Biotech Co. | RECRUITING |
[NCT06239272](https://clinicaltrials.gov/study/NCT06239272) | NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) | PHASE1 | St. Jude Children's Research Hospital | RECRUITING |
[NCT06638931](https://clinicaltrials.gov/study/NCT06638931) | Agnostic Therapy in Rare Solid Tumors | PHASE2 | Instituto do Cancer do Estado de São Paulo | RECRUITING |
[NCT04332874](https://clinicaltrials.gov/study/NCT04332874) | A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg | PHASE2 | Memorial Sloan Kettering Cancer Center | RECRUITING |
207 publications have been identified in PubMed for adult fibrosarcoma. Research spans Basic Science / Preclinical (32%), Review / Meta-Analysis (24%), and Case Report / Case Series (20%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 66 | 32% |
Research summaries | 50 | 24% |
Patient case studies | 41 | 20% |
Disease patterns and progression | 12 | 6% |
Clinical study results | 11 | 5% |
Testing and diagnosis research | 10 | 5% |
New treatment approaches | 10 | 5% |
Other research | 7 | 3% |
Crawford MJ (2026). [PMID: 41562145](https://pubmed.ncbi.nlm.nih.gov/41562145/). *J Vet Diagn Invest*. [Case Report / Case Series]
Thomas G (2026). [PMID: 41587909](https://pubmed.ncbi.nlm.nih.gov/41587909/). *J Small Anim Pract*. [Case Report / Case Series]
Wang Y (2026). [PMID: 41783920](https://pubmed.ncbi.nlm.nih.gov/41783920/). *Mater Horiz*. [Basic Science / Preclinical]
Johnson CP (2026). [PMID: 41923390](https://pubmed.ncbi.nlm.nih.gov/41923390/). *Vet Comp Oncol*. [Basic Science / Preclinical]
Kato M (2026). [PMID: 41888635](https://pubmed.ncbi.nlm.nih.gov/41888635/). *J Dermatol*. [Review / Meta-Analysis]
Escobar Howard M (2026). [PMID: 42046583](https://pubmed.ncbi.nlm.nih.gov/42046583/). *Cureus*. [Case Report / Case Series]
Pilkington T (2026). [PMID: 41369044](https://pubmed.ncbi.nlm.nih.gov/41369044/). *Am J Surg Pathol*. [Case Report / Case Series]
Feng X (2026). [PMID: 42236131](https://pubmed.ncbi.nlm.nih.gov/42236131/). *J Clin Pathol*. [Clinical Trial Publication]
Ventrici A (2026). [PMID: 41866888](https://pubmed.ncbi.nlm.nih.gov/41866888/). *J Immunol Res*. [Epidemiology / Natural History]
Marcinko M (2026). [PMID: 41929908](https://pubmed.ncbi.nlm.nih.gov/41929908/). *Case Rep Orthop*. [Case Report / Case Series]