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Back to Adult Glioblastoma

Adult Glioblastoma — NIH Grants & Funding

Active and recent NIH-funded research on Adult Glioblastoma. Data from NIH RePORTER, last 36 months.

MONDO:0020690

NIH-funded research on Adult Glioblastoma

202

active grants

institutions

282

researchers

new in last 12 mo.

$205.1M in NIH funding over the last 36 months. Data from NIH RePORTER.

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Basic Science(98)

Basic ScienceU54Active

Quantitative systems biology of glioblastoma cells and their interactions with the neuronal and immunological milieu

Michor, Franziska et al.·MASSACHUSETTS INSTITUTE OF TECHNOLOGY·CAMBRIDGE, MA

$2,002,011 (FY2025)

Adult Glioblastoma — NIH Grants & Funding

Basic Science(98)

Quantitative systems biology of glioblastoma cells and their interactions with the neuronal and immunological milieu

Targeting Glioblastoma Stem Cells

Pre-clinical Development of Radiation Sensitizers for Patients with Glioblastoma

Microenvironmental regulation of glioblastoma radiosensitivity

Systems biology of intratumoral heterogeneity in glioblastoma

Defining the role of cytomegalovirus in glioblastoma therapies

Harnessing YAP-TEAD Activity as Anti-Invasion Therapeutic in Human Glioblastoma

Understanding the cellular and functional changes in the immune tumor microenvironment of glioblastoma during progression and treatments.

Role of SMARCA5 in Glioblastoma

Unlocking the Immunobiology of Conventional Dendritic Cells to Augment T Cell Activation in Glioblastoma

Translational(83)

Understanding and Overcoming T cell Immunosuppression in Glioblastoma

Biomaterial-Enhanced CAR-T/NK Cell Therapies for Glioblastoma.

Targeting Myeloid Metabolism to Reprogram the Tumor Microenvironment of Glioblastoma

Tumor Antigen Targeted Nanoparticle Therapy for Glioblastoma (GBM)

Spherical Nucleic Acid nano-architectures as first-in-class cGAS agonists for the immunotherapeutic treatment of Glioblastoma.

Development of Small Molecule Inhibitors and Biologic Agents for Treatment of Glioblastoma Using Intracerebral Microdialysis and Signatures of Vulnerability

Connectivity mapping identified novel combination therapy for glioblastoma

Advancing treatment and understanding of immunotherapy in glioblastoma

6-thio-2'-deoxyguanosine: A Novel Immunogenic Telomerase-Mediated Therapy in Glioblastoma - A Duke and UTSW Collaboration

Sonodynamic therapy using MRI-guided focused ultrasound in combination with 5-aminolevulinic acid to treat recurrent glioblastoma multiforme

Clinical(30)

Phase 1b/2a Trial of QBS-72S for the Treatment of Newly Diagnosed Glioblastoma Multiforme in Patients with Unmethylated MGMT Promoters

Determining mechanisms of heterogeneous treatment response in glioblastoma using multi-omic and multi-organ approaches

Targeting T cell dysfunction in glioblastoma: A proof-of-concept Phase 0/I trial of anti-TIGIT antibody AB154 in combination with anti-PD1 antibody AB122

Dissecting Orchestrated Immune Responses to Glioblastoma within the Native Tissue Microenvironment to Improve Treatment Outcomes

Phase IIA Trial of Dichloroacetate for Glioblastoma Multiforme, IND137007, 09172019

Contribution of Myeloid-Derived Suppressor Cells to Neuro-Inflammatory Alterations and Disease Progression in Glioblastoma

Targeting physical stress-driven mechanisms to overcome glioblastoma treatment resistance

A Phase II Clinical Trial in Newly Diagnosed Glioblastoma Patients Treated with WP1066 and Radiation

Role of decorin and diffusion MRI in anti-VEGF efficacy for recurrent glioblastoma

Small molecule inhibitors of Slit2/Robo signaling as novel therapeutics for glioblastoma

Epi / Nat. History(1)

Oncolytic Virus Therapeutic Responses Occur from Changes in the Glioblastoma Immune Microenvironment

Gene/Cell Therapy(20)

Engineered Glioblastoma-specific T cells using Immunostimulatory Photothermal Nanoparticles

miR-10b Gene Editing Therapy for Glioblastoma

Epigenetic re-establishment of tumor suppression in glioblastoma

Engineered T cell-based imaging for glioblastoma and CAR-T cell tracking

Engineering mRNA encapsulated extracellular vesicles for in vivo chimeric antigen receptor macrophage therapy for glioblastoma

A phase I study of RNA-lipid particle vaccines for newly-diagnosed glioblastoma, IND19304 08/21/2020

Improving IL12 Immunogene Therapy for Glioblastoma Based on Human Clinical Trial Results

Enhanced Delivery of Cytotoxic Neural Stem Cells for Treatment of Glioblastoma Multiforme Using an Innovative In-situ Thermogelling Hydrogel and Focused Ultrasound

Programming multi-pronged immune response to glioblastoma with IL-13Ra2/TGF-b CAR-T cell therapy.

Neoantigen-specific Adoptive T Cell Therapy for Glioblastoma, IND-BB-13135, protocol submitted 04/25/2020

Biomarker / Dx(13)

Liquid Biopsy in Glioblastoma Treated with Chemoradiation and an Oxygen Therapeutic

Quantitative Glioblastoma Margin and Infiltration Mapping with Advanced Diffusion-Relaxation MRI

Quantitative imaging phenotypic classifier for distinguishing radiation effects from tumor recurrence in Glioblastoma

Sonobiopsy for Noninvasive Genetic Evaluation of Glioblastoma Patients

Generalizable quantitative imaging and machine learning signatures in glioblastoma, for precision diagnostics and personalized treatment: the ReSPOND consortium

Radiomic spatial maps for identifying viable tumor extent on multi-parametric MRI for Glioblastoma

Targeting Glioblastoma with Multifunctional Anti-RAGE Oligonucleotides

IDO1 and Immunotolerance in Glioblastoma

Epigenetic Biomarkers in Glioblastoma

Circulating Cell-Free DNA as a Personalized Biomarker to Diagnose and Monitor Glioblastoma Extension

Medical Device(3)

Tumor Monorail Device for Serial Glioblastoma Biopsy

MR Fingerprinting for Characterization and Prediction of Glioblastoma Infiltration

Preclinical assessment of efficacy and tumor microenvironment alterations by PPRX-1701 in glioblastoma

Other(4)

Novel lipid and glutamine metabolism-based combination therapies for glioblastoma

Defining Tumor Microenvironmental Interactions that drive THY1-Mediated Treatment Resistance in Glioblastoma

Deciphering the role of the novel long non-coding RNA LINC01896 in glioblastoma multiforme

ImmunoPET Evaluation of Focused Ultrasound-mediated Delivery and Immunomodulation by anti-CD47 Immunotherapy in the Setting of Current Standard-of-Care Treatment for Glioblastoma