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A malignant peripheral nerve sheath tumor occurring during adulthood.
Biomarker and diagnostic research for adult malignant schwannoma has been reported in the published literature.
15 clinical trials registered, 7 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 5 PHASE2, 5 PHASE1, 1 EARLY_PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06693284](https://clinicaltrials.gov/study/NCT06693284) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:45 AM UTC
Common questions about adult malignant schwannoma
A Window of Opportunity Trial of Mirdametinib Plus Vorinostat for NF1 Associated, H3K27 Trimethylation Deficient Malignant Peripheral Nerve Sheath Tumor [MPNST] |
EARLY_PHASE1 |
University of Minnesota |
RECRUITING |
[NCT04872543](https://clinicaltrials.gov/study/NCT04872543) | A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST) | PHASE2 | Memorial Sloan Kettering Cancer Center | RECRUITING |
[NCT06735820](https://clinicaltrials.gov/study/NCT06735820) | Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST | PHASE1 | AeRang Kim | RECRUITING |
[NCT04222413](https://clinicaltrials.gov/study/NCT04222413) | Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors | PHASE1 | National Cancer Institute (NCI) | RECRUITING |
[NCT06849986](https://clinicaltrials.gov/study/NCT06849986) | IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS) | PHASE2 | Fudan University | RECRUITING |
261 publications have been identified in PubMed for adult malignant schwannoma. Research spans Case Report / Case Series (44%), Review / Meta-Analysis (13%), and Basic Science / Preclinical (11%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 115 | 44% |
Research summaries | 34 | 13% |
Laboratory research | 29 | 11% |
Testing and diagnosis research | 28 | 11% |
Disease patterns and progression | 21 | 8% |
Clinical study results | 20 | 8% |
New treatment approaches | 9 | 3% |
Other research | 5 | 2% |
Zhou J (2026). [PMID: 42087684](https://pubmed.ncbi.nlm.nih.gov/42087684/). *Perm J*. [Case Report / Case Series]
Crane JN (2026). [PMID: 41386267](https://pubmed.ncbi.nlm.nih.gov/41386267/). *J Natl Cancer Inst*. [Epidemiology / Natural History]
Wei J (2026). [PMID: 41392993](https://pubmed.ncbi.nlm.nih.gov/41392993/). *Histopathology*. [Diagnostic / Biomarker]
Richman LP (2026). [PMID: 41881192](https://pubmed.ncbi.nlm.nih.gov/41881192/). *Mod Pathol*. [Diagnostic / Biomarker]
Vinciguerra A (2026). [PMID: 41025537](https://pubmed.ncbi.nlm.nih.gov/41025537/). *Int Forum Allergy Rhinol*. [Review / Meta-Analysis]
Santacroce A (2026). [PMID: 41318094](https://pubmed.ncbi.nlm.nih.gov/41318094/). *World neurosurgery*. [Clinical Trial Publication]
Kim A (2026). [PMID: 41504652](https://pubmed.ncbi.nlm.nih.gov/41504652/). *Clin Cancer Res*. [Clinical Trial Publication]
Qian L (2026). [PMID: 41526870](https://pubmed.ncbi.nlm.nih.gov/41526870/). *BMC Surg*. [Case Report / Case Series]
Shamoun F (2026). [PMID: 40834354](https://pubmed.ncbi.nlm.nih.gov/40834354/). *Pancreas*. [Case Report / Case Series]
Spencer-Taylor A (2026). [PMID: 42027815](https://pubmed.ncbi.nlm.nih.gov/42027815/). *Front Vet Sci*. [Case Report / Case Series]