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Features include always present findings: Early chronotype.
TIMELESS function has not been fully characterized.
Advance sleep phase syndrome, familial, 4 is associated with mutations in the TIMELESS gene on chromosome 12.
Genetic testing for TIMELESS is available. Testing is considered confirmatory for diagnosis.
Phenotype severity distribution: 1 always present feature.
No clinical trials have been registered for advance sleep phase syndrome, familial, 4.
3 publications have been identified in PubMed for advance sleep phase syndrome, familial, 4. Research spans Review / Meta-Analysis (67%) and Other (33%).
Traversa P (2025). [PMID: 40277796](https://pubmed.ncbi.nlm.nih.gov/40277796/). *Curr Oncol*. [Other]
Silvestri R (2025). [PMID: 39864932](https://pubmed.ncbi.nlm.nih.gov/39864932/). *Handb Clin Neurol*. [Review / Meta-Analysis]
Tonon AC (2024). [PMID: 39210713](https://pubmed.ncbi.nlm.nih.gov/39210713/). *Psychiatry Clin Neurosci*. [Review / Meta-Analysis]
Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 12:33 PM UTC
Online Mendelian Inheritance in Man
Common questions about advance sleep phase syndrome, familial, 4