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A very rare circadian rhythm sleep disorder characterized by very early sleep onset and offset possibly resulting in emotional and physical disruptions.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for advanced sleep phase syndrome.
3 publications have been identified in PubMed for advanced sleep phase syndrome. Research spans Review / Meta-Analysis (67%) and Other (33%).
Cuddapah VA (2025). [PMID: 40720646](https://pubmed.ncbi.nlm.nih.gov/40720646/). *Proc Natl Acad Sci U S A*. [Other]
Mascarella D (2025). [PMID: 41147997](https://pubmed.ncbi.nlm.nih.gov/41147997/). *Cephalalgia*. [Review / Meta-Analysis]
Silvestri R (2025). [PMID: 39864932](https://pubmed.ncbi.nlm.nih.gov/39864932/). *Handb Clin Neurol*. [Review / Meta-Analysis]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 6:21 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about advanced sleep phase syndrome