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A rare, systemic amyloidosis characterized by slowly progressive renal disease presenting with proteinuria, hypertension and decreased glomerular filtration rate leading to progressive renal failure. Histology reveals amyloid deposits of leukocyte chemotactic factor-2 protein in the renal cortical interstitium, tubular basement membranes, glomeruli and the vessel walls. Extra-renal deposits can be seen in the liver, lungs, spleen and adrenal glands.
Biomarker and diagnostic research for ALECT2 amyloidosis has been reported in the published literature.
No clinical trials have been registered for ALECT2 amyloidosis.
17 publications have been identified in PubMed for ALECT2 amyloidosis. Research spans Case Report / Case Series (53%), Basic Science / Preclinical (18%), and Review / Meta-Analysis (12%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 9 | 53% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 3:42 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about ALECT2 amyloidosis
3 |
18% |
Research summaries | 2 | 12% |
Disease patterns and progression | 2 | 12% |
Testing and diagnosis research | 1 | 6% |
Matarneh AS (2026). [PMID: 41694633](https://pubmed.ncbi.nlm.nih.gov/41694633/). *Clinical case reports*. [Case Report / Case Series]
Li L (2026). [PMID: 41749115](https://pubmed.ncbi.nlm.nih.gov/41749115/). *BMC nephrology*. [Diagnostic / Biomarker]
Zheng JL (2026). [PMID: 42173881](https://pubmed.ncbi.nlm.nih.gov/42173881/). *Nat Commun*. [Basic Science / Preclinical]
Afrin S (2026). [PMID: 41965342](https://pubmed.ncbi.nlm.nih.gov/41965342/). *Nat Commun*. [Basic Science / Preclinical]
Bu L (2025). [PMID: 40543932](https://pubmed.ncbi.nlm.nih.gov/40543932/). *Kidney international*. [Case Report / Case Series]
Hu AC (2025). [PMID: 40519331](https://pubmed.ncbi.nlm.nih.gov/40519331/). *Sage open pathology*. [Case Report / Case Series]
Gong Q (2025). [PMID: 40443630](https://pubmed.ncbi.nlm.nih.gov/40443630/). *Cureus*. [Case Report / Case Series]
Kumar A (2025). [PMID: 40490246](https://pubmed.ncbi.nlm.nih.gov/40490246/). *Archives of biochemistry and biophysics*. [Epidemiology / Natural History]
Afrin S (2025). [PMID: 40791318](https://pubmed.ncbi.nlm.nih.gov/40791318/). *bioRxiv : the preprint server for biology*. [Basic Science / Preclinical]
Pradella J (2025). [PMID: 40850966](https://pubmed.ncbi.nlm.nih.gov/40850966/). *Journal of nephrology*. [Case Report / Case Series]
AI-curated news mentioning ALECT2 amyloidosis
Updated Apr 11, 2026
New research published in PubMed reveals the structural polymorphism of ex-vivo ALECT2 amyloid fibrils using cryo-electron microscopy. This study enhances understanding of ALECT2-related pathologies and may inform future therapeutic strategies.