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Back to Alpha 1-Antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency — NIH Grants & Funding

Active and recent NIH-funded research on Alpha 1-Antitrypsin Deficiency. Data from NIH RePORTER, last 36 months.

MONDO:0013282

Looking for specific grants? The Recent Research tab lets you search and filter by topic.

Funding Landscape

Alpha 1-Antitrypsin Deficiency has active NIH research funding with 17 funded grants totaling $23.6M.

17funded grants from NIH

Portfolio: $9.9MCumulative: $23.6M7 active10 completed18 PIs11 institutions

1 new grant started in the last 12 months.

By Research Theme

Gene/Cell Therapy

Basic Science

Translational

Epi / Nat. History

Clinical

1 additional grant classified as “Other” (multi-disciplinary, infrastructure, etc.).

Funding by Fiscal Year

NIH fiscal year (Oct–Sep)

$7.2M

FY22

$4.6M

FY23

$4.9M

FY24

$6.8M

FY25

By Funding Mechanism

R01

F30

F31

K08

P01

R21

Funding Gap Analysis

Cross-referencing NIH grants against published research and clinical trials to identify funding-evidence gaps for Alpha 1-Antitrypsin Deficiency. Strongest funded area: Gene Therapy / Cell Therapy. Largest gap: Biomarker / Diagnostics.

Biomarker / DiagnosticsPublished, Not NIH-Funded

26 publications in Diagnostic / Biomarker but no NIH-funded grants found in Biomarker / Diagnostics for alpha 1-antitrypsin deficiency. Existing research activity suggests this may be a viable area for grant applications.

Adjacent Research(9 grants)

These grants mention Alpha 1-Antitrypsin Deficiency as part of broader research but are not primarily focused on this disease. They are not included in the funding totals above.

Other(9)

OtherU54Active

Rare Bronchiectatic Diseases Consortium

Boucher, Richard et al.·UNIV OF NORTH CAROLINA CHAPEL HILL·CHAPEL HILL, NC

$1,425,304 (FY2025)

NIH RePORTER

OtherR01Active

Managing Alpha-1-Antitrypsin Deficiency (AATD) through Proteostasis Signaling Pathways

Balch, William·SCRIPPS RESEARCH INSTITUTE, THE·LA JOLLA, CA

$855,694 (FY2026)

NIH RePORTER

OtherU01Completed

Clinical Center for Cholestatic Liver Disease in Children

Miethke, Alexander·CINCINNATI CHILDRENS HOSP MED CTR·CINCINNATI, OH

$801,000 (FY2023)

NIH RePORTER

OtherR01Completed

Mechanisms of DNA damage induced emphysema

Armanios, Mary·JOHNS HOPKINS UNIVERSITY·BALTIMORE, MD

$522,084 (FY2023)

NIH RePORTER

OtherU01Completed

The Pittsburgh Cholestatic Liver Disease Consortium

Horslen, Simon·UNIVERSITY OF PITTSBURGH AT PITTSBURGH·PITTSBURGH, PA

$500,000 (FY2023)

NIH RePORTER

OtherU01Completed

Continuation of ChiLDReN, the Childhood Liver Disease Research Network: Indiana University

Molleston, Jean·INDIANA UNIVERSITY INDIANAPOLIS·INDIANAPOLIS, IN

$480,000 (FY2023)

NIH RePORTER

OtherR01Completed

Novel Vector Platform for Gene Therapy

Curiel, David·WASHINGTON UNIVERSITY·SAINT LOUIS, MO

$370,126 (FY2022)

NIH RePORTER

OtherU01Completed

Childhood Liver Disease Research Network (ChiLDReN) Clinical Centers

Alonso, Estella·LURIE CHILDREN'S HOSPITAL OF CHICAGO·CHICAGO, IL

$360,000 (FY2023)

NIH RePORTER

OtherU01Completed

Childhood Liver Disease Research Network (ChiLDReN) - UCSF (CC)

ROSENTHAL, PHILIP·UNIVERSITY OF CALIFORNIA, SAN FRANCISCO·SAN FRANCISCO, CA

$130,000 (FY2023)

NIH RePORTER

NIH Grants & Funding for Alpha 1-Antitrypsin Deficiency | Kisho | Kisho

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Alpha 1-Antitrypsin Deficiency — NIH Grants & Funding

Funding Landscape

By Research Theme

Funding by Fiscal Year

By Funding Mechanism

Funding Gap Analysis

Adjacent Research(9 grants)

Other(9)

Rare Bronchiectatic Diseases Consortium

Managing Alpha-1-Antitrypsin Deficiency (AATD) through Proteostasis Signaling Pathways

Clinical Center for Cholestatic Liver Disease in Children

Mechanisms of DNA damage induced emphysema

The Pittsburgh Cholestatic Liver Disease Consortium

Continuation of ChiLDReN, the Childhood Liver Disease Research Network: Indiana University

Novel Vector Platform for Gene Therapy

Childhood Liver Disease Research Network (ChiLDReN) Clinical Centers

Childhood Liver Disease Research Network (ChiLDReN) - UCSF (CC)

Top Funded Institutions

Top Principal Investigators