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No approved treatments are currently available for alternating hemiplegia. An additional 1 compound holds orphan drug designation.
While no drugs are FDA-approved specifically for alternating hemiplegia, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.
The following drugs have received orphan drug designation from the FDA for alternating hemiplegia. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor |
|---|
1 clinical trial registered. Pipeline includes 1 PHASE2.
53 publications have been identified in PubMed for alternating hemiplegia. Research spans Case Report / Case Series (33%), Basic Science / Preclinical (25%), and Review / Meta-Analysis (23%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 17 | 33% |
Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 12:11 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Designated
Exclusivity End |
|---|
Designation Status |
|---|
flunarizine | flunarizine | Xenon Pharmaceuticals, Inc. | 2018 | — | Designated |
Gene therapy approaches for alternating hemiplegia have been reported in the published literature.
1 trial found
13 |
25% |
Research summaries | 12 | 23% |
Disease patterns and progression | 5 | 10% |
Other research | 2 | 4% |
New treatment approaches | 2 | 4% |
Clinical study results | 1 | 2% |
Errichiello G (2026). [PMID: 42151635](https://pubmed.ncbi.nlm.nih.gov/42151635/). *Neurol Sci*. [Case Report / Case Series]
Bernardi K (2026). [PMID: 41850905](https://pubmed.ncbi.nlm.nih.gov/41850905/). *Mov Disord*. [Case Report / Case Series]
Wall DA (2026). [PMID: 42079228](https://pubmed.ncbi.nlm.nih.gov/42079228/). *bioRxiv*. [Basic Science / Preclinical]
Lin A (2026). [PMID: 42003272](https://pubmed.ncbi.nlm.nih.gov/42003272/). *Mov Disord*. [Other]
Kravljanac R (2026). [PMID: 42187878](https://pubmed.ncbi.nlm.nih.gov/42187878/). *Diseases*. [Review / Meta-Analysis]
Leite JA (2026). [PMID: 41634807](https://pubmed.ncbi.nlm.nih.gov/41634807/). *Orphanet J Rare Dis*. [Review / Meta-Analysis]
Fortunato F (2026). [PMID: 41473933](https://pubmed.ncbi.nlm.nih.gov/41473933/). *Neurol Genet*. [Epidemiology / Natural History]
Yagita K (2026). [PMID: 41235412](https://pubmed.ncbi.nlm.nih.gov/41235412/). *Clin Neuropathol*. [Case Report / Case Series]
Wall DA (2026). [PMID: 42063340](https://pubmed.ncbi.nlm.nih.gov/42063340/). *Dis Model Mech*. [Basic Science / Preclinical]
Bidzimou MK (2026). [PMID: 41948929](https://pubmed.ncbi.nlm.nih.gov/41948929/). *JCI Insight*. [Basic Science / Preclinical]