Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

amoebiasis due to Entamoeba histolytica - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

amoebiasis due to Entamoeba histolytica

MONDO:0019028

Overview

A parasitic disease caused by the protozoa, Entamoeba histolytica, mainly occurring in tropical regions after the ingestion of an amoebic cyst, and resulting in clinical manifestations that may range from an asymptomatic state to amoebic colitis (violent abdominal pain, a painful contracted feeling around the anal sphincter, blood and mucus in the stools but without the presence of fever), or amoebic liver abscesses (fever, chills, abdominal pain, weight loss, hepatomegaly) that can be fatal if not immediately treated. Extraintestinal involvement elsewhere (i.e. thoracic, hepatic) is extremely rare.

ResearchLimited published research (5 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include sometimes findings: Weight loss, Diarrhea, Abdominal pain, and Gastrointestinal dysmotility and others; and rarely findings: Congestive heart failure, Abnormal membrane around the heart (abnormal pericardium morphology), Low red blood cell count (anemia), and Fever and others.

Organ System	Phenotype Count	Example Features
Digestive system	9	Diarrhea, Abdominal pain, Gastrointestinal dysmotility

Diagnosis

Biomarker and diagnostic research for amoebiasis due to Entamoeba histolytica has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for amoebiasis due to Entamoeba histolytica.

5 publications have been identified in PubMed for amoebiasis due to Entamoeba histolytica. Research spans Diagnostic / Biomarker (60%), Case Report / Case Series (20%), and Basic Science / Preclinical (20%).

Recent Publications

Mujica R (2026). [PMID: 42086149](https://pubmed.ncbi.nlm.nih.gov/42086149/). *J Microbiol Methods*. [Diagnostic / Biomarker]
Abed ZM (2025). [PMID: 40747509](https://pubmed.ncbi.nlm.nih.gov/40747509/). *Iran J Parasitol*. [Diagnostic / Biomarker]
Sharma S (2025). [PMID: 40835601](https://pubmed.ncbi.nlm.nih.gov/40835601/). *Nat Commun*. [Basic Science / Preclinical]
Yagüe Parada Á (2025). [PMID: 39559918](https://pubmed.ncbi.nlm.nih.gov/39559918/). *Rev Esp Enferm Dig*. [Case Report / Case Series]
Datta P (2025). [PMID: 40471554](https://pubmed.ncbi.nlm.nih.gov/40471554/). *Trans R Soc Trop Med Hyg*. [Diagnostic / Biomarker]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 5:36 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:67

GARD

Genetic and Rare Diseases Info Center

GARD:18675

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

amoebiasis due to Entamoeba histolytica

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features