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Infection by hookworms of the genus Ancylostoma.
Biomarker and diagnostic research for ancylostomiasis has been reported in the published literature.
No approved treatments are currently available for ancylostomiasis. An additional 1 compound holds orphan drug designation.
While no drugs are FDA-approved specifically for ancylostomiasis, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.
The following drugs have received orphan drug designation from the FDA for ancylostomiasis. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor |
|---|
Estimated prevalence: Unknown (Unknown prevalence).
4 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and biologic therapy. Pipeline includes 3 PHASE3, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
184 publications have been identified in PubMed for ancylostomiasis. Research spans Review / Meta-Analysis (32%), Basic Science / Preclinical (22%), and Epidemiology / Natural History (19%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 48 |
Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 12:59 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Designated
Exclusivity End |
|---|
Designation Status |
|---|
flubendazole | flubendazole | Zero Point Five Therapeutics | 2024 | — | Designated |
Gene therapy approaches for ancylostomiasis have been reported in the published literature.
4 trials found
Laboratory research | 33 | 22% |
Disease patterns and progression | 28 | 19% |
Patient case studies | 18 | 12% |
Clinical study results | 10 | 7% |
Testing and diagnosis research | 7 | 5% |
New treatment approaches | 3 | 2% |
Other research | 2 | 1% |
Puca E (2026). [PMID: 41966475](https://pubmed.ncbi.nlm.nih.gov/41966475/). *Parasitol Int*. [Case Report / Case Series]
Ngui R (2026). [PMID: 42223710](https://pubmed.ncbi.nlm.nih.gov/42223710/). *Acta Parasitol*. [Case Report / Case Series]
Hoogerwerf MA (2026). [PMID: 41926449](https://pubmed.ncbi.nlm.nih.gov/41926449/). *PLoS Negl Trop Dis*. [Review / Meta-Analysis]
Pham TND (2026). [PMID: 41818267](https://pubmed.ncbi.nlm.nih.gov/41818267/). *PLoS neglected tropical diseases*. [Case Report / Case Series]
Geary TG (2026). [PMID: 41851772](https://pubmed.ncbi.nlm.nih.gov/41851772/). *Parasites & vectors*. [Review / Meta-Analysis]
Thakur M (2026). [PMID: 41990408](https://pubmed.ncbi.nlm.nih.gov/41990408/). *Indian J Med Microbiol*. [Diagnostic / Biomarker]
Bradbury RS (2026). [PMID: 41666447](https://pubmed.ncbi.nlm.nih.gov/41666447/). *Am J Trop Med Hyg*. [Case Report / Case Series]
Jayakody N (2026). [PMID: 41671284](https://pubmed.ncbi.nlm.nih.gov/41671284/). *PLoS neglected tropical diseases*. [Epidemiology / Natural History]
Pattanawongsa A (2026). [PMID: 41631557](https://pubmed.ncbi.nlm.nih.gov/41631557/). *Tropical medicine & international health : TM & IH*. [Clinical Trial Publication]
Sayasone S (2026). [PMID: 41555461](https://pubmed.ncbi.nlm.nih.gov/41555461/). *Infectious diseases of poverty*. [Clinical Trial Publication]