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angiostrongyliasis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

angiostrongyliasis

MONDO:0019143

Overview

A foodborne zoonotic disease, endemic to Southeast Asia and the Pacific Islands, caused by the rat lungworm Angiostrongylus cantonensis and that is acquired by the ingestion of the infective larvae on vegetables or in raw or undercooked snails, slugs, land crabs, freshwater shrimps, frogs and lizards. The main feature is eosinophilic meningitis, with clinical manifestations including fever, headache, malaise, fatigue, vomiting, rhinorrhea, blurred vision, diplopia, cough, stiff neck, enteritis, constipation and paraesthesia due to the movement of the worms from the intestines to the lungs, central nervous system and eyes. In severe cases without treatment, coma and death can occur.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Headache, CSF pleocytosis, and Severely increased total eosinophil count; and common findings: Diplopia, Irritability, Excessive daytime somnolence, and Meningitis and others. 39 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	12	Headache, Irritability, Excessive daytime somnolence

Diagnosis

Biomarker and diagnostic research for angiostrongyliasis has been reported in the published literature.

Prognosis

Phenotype severity distribution: 3 very common features, 19 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for angiostrongyliasis.

54 publications have been identified in PubMed for angiostrongyliasis. Research spans Basic Science / Preclinical (28%), Case Report / Case Series (20%), and Review / Meta-Analysis (15%).

Research Type	Count	% of Total
Laboratory research	15	28%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:44 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:74

GARD

Genetic and Rare Diseases Info Center

GARD:683

Questions for Your Care Team

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angiostrongyliasis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

angiostrongyliasis

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications