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Arachnoiditis (ARC) is a chronic inflammation of the arachnoid layer of the meninges, of which adhesive arachnoiditis is the most severe form, characterized by debilitating, intractable neurogenic back and limb pain and a range of other neurological problems.
Features include very common findings: Tinnitus, Hearing loss (hearing impairment), Abnormality of the eye, and Abnormality of vision and others; and common findings: Anhidrosis. 15 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 7 | Hydrocephalus, Sensory neuropathy, Hyporeflexia |
Biomarker and diagnostic research for arachnoiditis has been reported in the published literature.
Phenotype severity distribution: 10 very common features, 1 common feature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for arachnoiditis.
105 publications have been identified in PubMed for arachnoiditis. Research spans Case Report / Case Series (47%), Basic Science / Preclinical (23%), and Review / Meta-Analysis (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 49 | 47% |
Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 1:39 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Ears
2 |
Tinnitus, Hearing loss (hearing impairment) |
Eyes | 2 | Abnormality of the eye, Abnormality of vision |
Skin | 1 | Anhidrosis |
Muscles | 1 | Muscle weakness |
Bones and joints | 1 | Arthralgia |
Kidneys and urinary system | 1 | Urinary bladder sphincter dysfunction |
24 |
23% |
Research summaries | 14 | 13% |
Disease patterns and progression | 6 | 6% |
Testing and diagnosis research | 5 | 5% |
Clinical study results | 5 | 5% |
Other research | 1 | 1% |
New treatment approaches | 1 | 1% |
Endo A (2026). [PMID: 41859523](https://pubmed.ncbi.nlm.nih.gov/41859523/). *NMC Case Rep J*. [Case Report / Case Series]
Demir G (2026). [PMID: 42017697](https://pubmed.ncbi.nlm.nih.gov/42017697/). *Am J Hosp Palliat Care*. [Case Report / Case Series]
Guo M (2026). [PMID: 41815492](https://pubmed.ncbi.nlm.nih.gov/41815492/). *Frontiers in neuroscience*. [Case Report / Case Series]
Haddad M (2026). [PMID: 41606491](https://pubmed.ncbi.nlm.nih.gov/41606491/). *BMC neurology*. [Case Report / Case Series]
Han G (2026). [PMID: 41808393](https://pubmed.ncbi.nlm.nih.gov/41808393/). *CNS neuroscience & therapeutics*. [Review / Meta-Analysis]
D'Amico RS (2026). [PMID: 41847840](https://pubmed.ncbi.nlm.nih.gov/41847840/). *Cancer reports (Hoboken, N.J.)*. [Case Report / Case Series]
Martin L (2026). [PMID: 41701027](https://pubmed.ncbi.nlm.nih.gov/41701027/). *Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners*. [Case Report / Case Series]
Raft J (2026). [PMID: 42097679](https://pubmed.ncbi.nlm.nih.gov/42097679/). *Reg Anesth Pain Med*. [Other]
Mehta SR (2026). [PMID: 41799265](https://pubmed.ncbi.nlm.nih.gov/41799265/). *Open forum infectious diseases*. [Gene Therapy / Novel Therapeutics]
Doat-Sarfati V (2026). [PMID: 41781151](https://pubmed.ncbi.nlm.nih.gov/41781151/). *Regional anesthesia and pain medicine*. [Case Report / Case Series]