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An IDH-mutant anaplastic astrocytoma that is characterized by the presence of increased mitotic activity and anaplastic features.
Biomarker and diagnostic research for astrocytoma, IDH-mutant, grade 3 has been reported in the published literature.
6 clinical trials registered, 4 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 2 PHASE3, 4 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06815029](https://clinicaltrials.gov/study/NCT06815029) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 3:07 PM UTC
Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma |
PHASE1 |
City of Hope Medical Center |
RECRUITING |
[NCT06860594](https://clinicaltrials.gov/study/NCT06860594) | Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma | PHASE1 | National Cancer Institute (NCI) | UNKNOWN |
[NCT07215910](https://clinicaltrials.gov/study/NCT07215910) | Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer | PHASE3 | Alliance for Clinical Trials in Oncology | RECRUITING |
[NCT07468136](https://clinicaltrials.gov/study/NCT07468136) | Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas | PHASE1 | Mayo Clinic | RECRUITING |
[NCT05303519](https://clinicaltrials.gov/study/NCT05303519) | SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance) | PHASE3 | Nuvation Bio Inc. | RECRUITING |
150 publications have been identified in PubMed for astrocytoma, IDH-mutant, grade 3. Research spans Basic Science / Preclinical (30%), Epidemiology / Natural History (17%), and Diagnostic / Biomarker (16%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 45 | 30% |
Disease patterns and progression | 25 | 17% |
Testing and diagnosis research | 24 | 16% |
Clinical study results | 22 | 15% |
Research summaries | 18 | 12% |
Patient case studies | 13 | 9% |
New treatment approaches | 3 | 2% |
Müller KJ (2026). [PMID: 42216973](https://pubmed.ncbi.nlm.nih.gov/42216973/). *Eur J Nucl Med Mol Imaging*. [Diagnostic / Biomarker]
Bao Z (2026). [PMID: 41821581](https://pubmed.ncbi.nlm.nih.gov/41821581/). *Cancer communications (London, England)*. [Clinical Trial Publication]
Müther M (2026). [PMID: 40926130](https://pubmed.ncbi.nlm.nih.gov/40926130/). *European journal of nuclear medicine and molecular imaging*. [Clinical Trial Publication]
Hoogstrate Y (2026). [PMID: 41850239](https://pubmed.ncbi.nlm.nih.gov/41850239/). *Cell Rep Med*. [Diagnostic / Biomarker]
Dipasquale A (2026). [PMID: 41604034](https://pubmed.ncbi.nlm.nih.gov/41604034/). *J Neurooncol*. [Epidemiology / Natural History]
Karsonovich T (2026). [PMID: 32809503](https://pubmed.ncbi.nlm.nih.gov/32809503/). *Unknown Journal*. [Review / Meta-Analysis]
Agarwal A (2026). [PMID: 41843543](https://pubmed.ncbi.nlm.nih.gov/41843543/). *Prague Med Rep*. [Epidemiology / Natural History]
McDonald MF (2026). [PMID: 41962162](https://pubmed.ncbi.nlm.nih.gov/41962162/). *J Neurosurg*. [Basic Science / Preclinical]
Goyal S (2026). [PMID: 42087646](https://pubmed.ncbi.nlm.nih.gov/42087646/). *Neurol India*. [Review / Meta-Analysis]
Ng S (2026). [PMID: 42102408](https://pubmed.ncbi.nlm.nih.gov/42102408/). *J Neurosurg*. [Case Report / Case Series]