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astrocytoma, IDH-mutant, grade 4 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

astrocytoma, IDH-mutant, grade 4

MONDO:0956981

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Overview

An IDH-mutant anaplastic astrocytoma that is characterized by the presence of necrosis and/or microvascular proliferation or homozygous deletion of CDKN2A and/or CDKN2B genes. The term glioblastoma no longer applies to central nervous system WHO grade 4 IDH-mutant astrocytomas.

Clinical Trials10 registered · 6 recruiting

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

10 clinical trials registered, 6 recruiting. Interventions under study include procedural interventions, biologic therapy, drug therapy, and other interventions. Pipeline includes 1 PHASE3, 2 PHASE2, 6 PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06623565](https://clinicaltrials.gov/study/NCT06623565)

Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 7:09 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 10 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Clinical study results	4	33%
Patient case studies	3	25%
Laboratory research	3	25%
Research summaries	1	8%
Disease patterns and progression	1	8%

astrocytoma, IDH-mutant, grade 4

Overview

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications