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autoimmune encephalopathy with parasomnia and obstructive sleep apnea - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

autoimmune encephalopathy with parasomnia and obstructive sleep apnea

MONDO:0018489

Also known as:anti-IgLON5 disease

Overview

Autoimmune encephalopathy with parasomnia and obstructive sleep apnea is a rare neurologic disorder characterized by a unique non-REM and REM parasomnia with sleep breathing dysfunction, gait instability and repetitive episodes of respiratory insufficiency, as well as autoantibodies against IgLON5. Patients may present stridor, chorea, limb ataxia, abnormal ocular movements, and bulbar symptoms (i.e. dysphagia, dysarthria, episodic central hypoventilation) with normal brain MRI. Excessive day sleepiness and cognitive deterioration have also been reported.

Diagnosis

Biomarker and diagnostic research for autoimmune encephalopathy with parasomnia and obstructive sleep apnea has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for autoimmune encephalopathy with parasomnia and obstructive sleep apnea.

68 publications have been identified in PubMed for autoimmune encephalopathy with parasomnia and obstructive sleep apnea. Research spans Case Report / Case Series (37%), Review / Meta-Analysis (22%), and Basic Science / Preclinical (16%).

Research Type	Count	% of Total
Patient case studies	25	37%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 3:12 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:420789

GARD

Genetic and Rare Diseases Info Center

GARD:21749

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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autoimmune encephalopathy with parasomnia and obstructive sleep apnea

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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