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narcolepsy without cataplexy - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

narcolepsy without cataplexy

MONDO:0019371

Also known as:narcolepsy type 2

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Overview

A type of narcolepsy characterized by excessive day-time sleepiness associated with uncontrollable sleep urges and sometimes paralysis at sleep, hypnagogic hallucinations and automatic behavior.

Clinical Trials3 registered · 2 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Hallucinations, Excessive daytime somnolence, Sleep disturbance, and Insomnia; and sometimes findings: Atypical behavior.

Organ System	Phenotype Count	Example Features
Brain and nerves	4	Atypical behavior, Hallucinations, Excessive daytime somnolence

Explore clinical features

Diagnosis

Biomarker and diagnostic research for narcolepsy without cataplexy has been reported in the published literature.

Prognosis

Phenotype severity distribution: 4 very common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered, 2 recruiting. Interventions under study include other interventions and drug therapy. Pipeline includes 1 PHASE2, 1 NA. Research is sponsored by a mix of industry and academic institutions.

74 publications have been identified in PubMed for narcolepsy without cataplexy. Research spans Epidemiology / Natural History (25%), Review / Meta-Analysis (24%), and Basic Science / Preclinical (16%).

Research Type	Count	% of Total
Disease patterns and progression	17

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 7:13 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:83465

GARD

Genetic and Rare Diseases Info Center

GARD:19038

Questions for Your Care Team

→Are any of the 3 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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narcolepsy without cataplexy

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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