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autosomal dominant epilepsy with auditory features (ADEAF) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

autosomal dominant epilepsy with auditory features

MONDO:0010898

Also known as:ADEAFADLTEADPEAF

Overview

A rare, genetic, familial partial epilepsy disease characterized by focal seizures associated with prominent ictal auditory symptoms, and/or receptive aphasia, presenting in two or more family members and having a relatively benign evolution.

ResearchLimited published research (4 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Focal-onset seizure, Auditory hallucination, and EEG with focal epileptiform discharges; and common findings: Aphasia and Interictal epileptiform activity. 17 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	16	Focal-onset seizure, Auditory hallucination, EEG with focal epileptiform discharges

Prognosis

Phenotype severity distribution: 3 very common features, 2 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for autosomal dominant epilepsy with auditory features.

4 publications have been identified in PubMed for autosomal dominant epilepsy with auditory features. Research spans Case Report / Case Series (50%) and Basic Science / Preclinical (50%).

Recent Publications

M YK (2026). [PMID: 42150140](https://pubmed.ncbi.nlm.nih.gov/42150140/). *Neurology*. [Case Report / Case Series]
Hirano Y (2025). [PMID: 40455867](https://pubmed.ncbi.nlm.nih.gov/40455867/). *Brain : a journal of neurology*. [Basic Science / Preclinical]
Ramirez-Franco J (2024). [PMID: 38663634](https://pubmed.ncbi.nlm.nih.gov/38663634/). *Neurobiol Dis*. [Basic Science / Preclinical]
Bonanni P (2024). [PMID: 38654463](https://pubmed.ncbi.nlm.nih.gov/38654463/). *Epilepsia Open*. [Case Report / Case Series]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 4:30 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:101046

GARD

Genetic and Rare Diseases Info Center

GARD:2257

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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autosomal dominant epilepsy with auditory features

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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