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A childhood-onset epilepsy syndrome that is characterized by onset of seizures between 3 and 14 years (peak 8-9 years) that usually resolve by age 13 years, but can occasionally occur up to age 18 years of age. Both sexes are affected. Antecedent, birth and neonatal history is normal. A history of febrile seizure (in 5-15%) may be seen. A history of Panayiotopoulos syndrome may be present in a very small number of cases. Neurological exam and head size is normal. Development and cognition prior to onset of seizures is normal. During the course of the active epilepsy, behavioral and neuropsychological deficits may be found, particularly in language and executive functioning. These deficits improve when seizures remit.
Features include: Bilateral tonic-clonic seizure with focal onset, Nocturnal seizures, Focal-onset seizure, and EEG with centrotemporal focal spike waves.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 3 | Bilateral tonic-clonic seizure with focal onset, Nocturnal seizures, Focal-onset seizure |
Biomarker and diagnostic research for self-limited epilepsy with centrotemporal spikes has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.
73 publications have been identified in PubMed for self-limited epilepsy with centrotemporal spikes. Research spans Basic Science / Preclinical (41%), Diagnostic / Biomarker (22%), and Epidemiology / Natural History (12%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 30 | 41% |
Testing and diagnosis research | 16 | 22% |
Disease patterns and progression | 9 | 12% |
Clinical study results | 7 | 10% |
Research summaries | 4 | 5% |
Patient case studies | 4 | 5% |
Other research | 2 | 3% |
New treatment approaches | 1 | 1% |
Zhou X (2026). [PMID: 41707906](https://pubmed.ncbi.nlm.nih.gov/41707906/). *Neuroscience*. [Basic Science / Preclinical]
Kwon H (2026). [PMID: 41435615](https://pubmed.ncbi.nlm.nih.gov/41435615/). *Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology*. [Clinical Trial Publication]
Iasinovschi N (2026). [PMID: 41353983](https://pubmed.ncbi.nlm.nih.gov/41353983/). *Epilepsy research*. [Diagnostic / Biomarker]
Yang S (2026). [PMID: 41725458](https://pubmed.ncbi.nlm.nih.gov/41725458/). *CNS neuroscience & therapeutics*. [Epidemiology / Natural History]
Margheri V (2026). [PMID: 41691780](https://pubmed.ncbi.nlm.nih.gov/41691780/). *Seizure*. [Clinical Trial Publication]
Vasitas ME (2026). [PMID: 41910930](https://pubmed.ncbi.nlm.nih.gov/41910930/). *Epilepsia*. [Basic Science / Preclinical]
Zhang Q (2026). [PMID: 42051563](https://pubmed.ncbi.nlm.nih.gov/42051563/). *Front Neurosci*. [Basic Science / Preclinical]
Lacey AS (2026). [PMID: 41352324](https://pubmed.ncbi.nlm.nih.gov/41352324/). *Seizure*. [Epidemiology / Natural History]
Amrutkar CV (2026). [PMID: 30521266](https://pubmed.ncbi.nlm.nih.gov/30521266/). *Unknown Journal*. [Case Report / Case Series]
Kızıl H (2026). [PMID: 41985205](https://pubmed.ncbi.nlm.nih.gov/41985205/). *Epilepsy Behav*. [Clinical Trial Publication]
Data assembled from 6 of 12 sources · Last updated Sep 20, 2026, 3:05 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center