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autosomal dominant nonsyndromic hearing loss 15 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

autosomal dominant nonsyndromic hearing loss 15

MONDO:0011226

Also known as:DFNA15POU4F3 autosomal dominant nonsyndromic deafnessautosomal dominant deafness 15

Overview

Any autosomal dominant nonsyndromic deafness in which the cause of the disease is a mutation in the POU4F3 gene.

GeneticsAutosomal dominant · POU4F3 (chr 5)

Clinical Presentation

Features include always present findings: Hearing loss (hearing impairment).

Organ System	Phenotype Count	Example Features
Ears	1	Hearing loss (hearing impairment)

Explore clinical features

Genetic Landscape

POU4F3 function has not been fully characterized.

Autosomal dominant nonsyndromic hearing loss 15 is associated with mutations in the POU4F3 gene on chromosome 5.

Diagnosis

Drawn from GeneReviews diagnostic guidelines, newborn screening panel status (RUSP), and ClinGen gene-disease validity classifications. Reflects current clinical evidence and consensus where available.

Genetic testing for POU4F3 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for autosomal dominant nonsyndromic hearing loss 15 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for autosomal dominant nonsyndromic hearing loss 15.

21 publications have been identified in PubMed for autosomal dominant nonsyndromic hearing loss 15. Research spans Basic Science / Preclinical (42%), Case Report / Case Series (32%), and Review / Meta-Analysis (11%).

Research Type	Count	% of Total
Laboratory research	8	42%

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 1:01 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:602459

GARD

Genetic and Rare Diseases Info Center

GARD:18109

Questions for Your Care Team

→Should I pursue genetic testing for POU4F3, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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autosomal dominant nonsyndromic hearing loss 15

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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