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hearing loss, autosomal dominant 88 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hearing loss, autosomal dominant 88

MONDO:0859527

Overview

GeneticsAutosomal dominant · EPHA10 (chr 1)

ResearchLimited published research (3 articles)

Clinical Presentation

Features include: Hearing loss (hearing impairment).

Organ System	Phenotype Count	Example Features
Ears	1	Hearing loss (hearing impairment)

Explore clinical features

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

EPHA10 encodes EPH receptor A10 (1,008 aa). Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5 Highest expression in Testis (33.1 TPM) and Colon Transverse (14.7 TPM).

Hearing loss, autosomal dominant 88 is associated with mutations in the EPHA10 gene on chromosome 1.

EPHA10 is classified as a druggable target (Druggable Genome, Kinase, and Tyrosine Kinase categories) with score 0.9.

Diagnosis

Genetic testing for EPHA10 is available. Testing is considered confirmatory for diagnosis.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hearing loss, autosomal dominant 88.

4 publications have been identified in PubMed for hearing loss, autosomal dominant 88. Kisho has analyzed 3 by research type. Research spans Case Report / Case Series (67%) and Review / Meta-Analysis (33%).

Recent Publications

Khandelwal S (2026). [PMID: 41675840](https://pubmed.ncbi.nlm.nih.gov/41675840/). *Ann Med Surg (Lond)*. [Case Report / Case Series]
Zhang JJ (2025). [PMID: 40777921](https://pubmed.ncbi.nlm.nih.gov/40777921/). *Pediatr Diabetes*. [Case Report / Case Series]
Patil V (2024). [PMID: 38970134](https://pubmed.ncbi.nlm.nih.gov/38970134/). *Clin Epigenetics*. [Review / Meta-Analysis]

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 6:06 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:620283

Questions for Your Care Team

→Should I pursue genetic testing for EPHA10, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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hearing loss, autosomal dominant 88

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Related Diseases

Questions for Your Care Team

Questions for Your Care Team