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autosomal recessive nonsyndromic hearing loss 21 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

autosomal recessive nonsyndromic hearing loss 21

MONDO:0011351

Also known as:DFNB21TECTA autosomal recessive nonsyndromic deafnessautosomal recessive deafness 21

Overview

Any autosomal recessive nonsyndromic deafness in which the cause of the disease is a mutation in the TECTA gene.

GeneticsAutosomal recessive · TECTA (chr 11)

OnsetINFANTILE

Clinical Presentation

Features include: Inner ear hearing loss (sensorineural hearing impairment).

Organ System	Phenotype Count	Example Features
Ears	1	Inner ear hearing loss (sensorineural hearing impairment)

Age of onset: infancy.

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Genetic Landscape

TECTA function has not been fully characterized.

Autosomal recessive nonsyndromic hearing loss 21 is associated with mutations in the TECTA gene on chromosome 11.

Diagnosis

Genetic testing for TECTA is available. Testing is considered confirmatory for diagnosis.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for autosomal recessive nonsyndromic hearing loss 21.

23 publications have been identified in PubMed for autosomal recessive nonsyndromic hearing loss 21. Research spans Basic Science / Preclinical (45%), Case Report / Case Series (18%), and Epidemiology / Natural History (14%).

Research Type	Count	% of Total
Laboratory research	10	45%

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 1:27 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:603629

GARD

Genetic and Rare Diseases Info Center

GARD:22595

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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autosomal recessive nonsyndromic hearing loss 21

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

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