CDC14A encodes cell division cycle 14A (594 aa). Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. Highest expression in Testis (28.2 TPM) and Lung (8.8 TPM).

Autosomal recessive nonsyndromic hearing loss 32 is associated with mutations in the CDC14A gene on chromosome 1.

The CDC14A protein participates in p-3S,T MAPK6:CDC14A,B and CDC14A,B bind MAPK6 pathways.

CDC14A is classified as a druggable target (Druggable Genome, Enzyme, and Protein Phosphatase categories) with score 0.0.

Genetic testing for CDC14A is available. Testing is considered confirmatory for diagnosis.

Phenotype severity distribution: 1 always present feature, 1 common feature.

No clinical trials have been registered for autosomal recessive nonsyndromic hearing loss 32.

3 publications have been identified in PubMed for autosomal recessive nonsyndromic hearing loss 32. Kisho has analyzed 2 by research type. Research spans Case Report / Case Series (100%).

Recent Publications

• Gan H (2026). [PMID: 41578500](https://pubmed.ncbi.nlm.nih.gov/41578500/). *Medicine (Baltimore)*. [Case Report / Case Series]

• Kumar U (2026). [PMID: 42083422](https://pubmed.ncbi.nlm.nih.gov/42083422/). *J Genet*. [Case Report / Case Series]