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autosomal recessive nonsyndromic hearing loss 97 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

autosomal recessive nonsyndromic hearing loss 97

MONDO:0014739

Also known as:DFNB97MET autosomal recessive nonsyndromic deafnessautosomal recessive deafness 97

Overview

Any autosomal recessive nonsyndromic deafness in which the cause of the disease is a mutation in the MET gene.

GeneticsAutosomal recessive · MET (chr 7)

OnsetINFANTILE

ResearchLimited published research (8 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Inner ear hearing loss (sensorineural hearing impairment).

Organ System	Phenotype Count	Example Features
Ears	1	Inner ear hearing loss (sensorineural hearing impairment)

Age of onset: infancy.

Explore clinical features

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

MET encodes MET proto-oncogene, receptor tyrosine kinase (1,390 aa). Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Highest expression in Nerve Tibial (21.3 TPM) and Cells Cultured fibroblasts (18.5 TPM).

Autosomal recessive nonsyndromic hearing loss 97 is associated with mutations in the MET gene on chromosome 7.

The MET protein participates in GNAT1 (Met removed) and Signaling by MET pathways.

MET is classified as a druggable target (Cell Surface, Clinically Actionable, Drug Resistance, Druggable Genome, Kinase, and Tyrosine Kinase categories) with score 3.5.

Diagnosis

Drawn from GeneReviews diagnostic guidelines, newborn screening panel status (RUSP), and ClinGen gene-disease validity classifications. Reflects current clinical evidence and consensus where available.

Genetic testing for MET is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for autosomal recessive nonsyndromic hearing loss 97 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for autosomal recessive nonsyndromic hearing loss 97.

8 publications have been identified in PubMed for autosomal recessive nonsyndromic hearing loss 97. Research spans Basic Science / Preclinical (38%), Diagnostic / Biomarker (13%), and Review / Meta-Analysis (13%).

Recent Publications

Jiang L (2026). [PMID: 42020731](https://pubmed.ncbi.nlm.nih.gov/42020731/). *Nature*. [Gene Therapy / Novel Therapeutics]
Kayhan G (2026). [PMID: 41751633](https://pubmed.ncbi.nlm.nih.gov/41751633/). *Genes (Basel)*. [Basic Science / Preclinical]
Long X (2025). [PMID: 40410890](https://pubmed.ncbi.nlm.nih.gov/40410890/). *Hum Genomics*. [Basic Science / Preclinical]
Wan Y (2025). [PMID: 40677922](https://pubmed.ncbi.nlm.nih.gov/40677922/). *Hum Mutat*. [Basic Science / Preclinical]
Tsuji RK (2025). [PMID: 39442262](https://pubmed.ncbi.nlm.nih.gov/39442262/). *Braz J Otorhinolaryngol*. [Review / Meta-Analysis]

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 7:10 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:616705

GARD

Genetic and Rare Diseases Info Center

GARD:22655

Questions for Your Care Team

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autosomal recessive nonsyndromic hearing loss 97

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

Questions for Your Care Team