Autosomal recessive spastic paraplegia type 70 is a very rare, complex subtype of hereditary spastic paraplegia that presents in infancy with delayed motor development (i.e. crawling, walking) and is ...
Comprehensive, easy-to-understand information about this condition
How we create this content →Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 7, 2026
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 7, 2026
The documentation for autosomal recessive spastic paraplegia type 70 is limited due to its extreme rarity, affecting fewer than 1 in 1,000,000 individuals worldwide. This rarity restricts the ability to conduct systematic clinical studies, which are essential for understanding the full spectrum of the condition. Additionally, the genetic basis remains unidentified, complicating efforts to characterize the disorder and its inheritance patterns.
The clinical features of autosomal recessive spastic paraplegia type 70 primarily affect the nervous system and motor function. Most commonly, patients exhibit progressive spastic paraplegia, which manifests as lower limb spasticity and abnormal movement patterns. Peripheral neuropathy and abnormal myelination may also be present, contributing to global developmental delays and mild intellectual disability. Other notable symptoms include hand tremors and potential scoliosis.
To navigate your journey with autosomal recessive spastic paraplegia type 70, consider seeking a neurologist with expertise in hereditary spastic paraplegias. While there are currently no identified patient organizations, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information and support. Genetic counseling may be beneficial, especially for family planning discussions, as understanding the genetic components of rare diseases can be complex. Additionally, inquire about any local support groups or networks for families dealing with rare neurological conditions.
Actionable guidance for navigating care for autosomal recessive spastic paraplegia type 70
To navigate your journey with autosomal recessive spastic paraplegia type 70, consider seeking a neurologist with expertise in hereditary spastic paraplegias. While there are currently no identified patient organizations, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can provide valuable information and support. Genetic counseling may be beneficial, especially for family planning discussions, as understanding the genetic components of rare diseases can be complex. Additionally, inquire about any local support groups or networks for families dealing with rare neurological conditions.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Clinical profile data for this condition is not yet available. Phenotype information may still be loading below.
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 7, 2026
Consider asking your healthcare providers these condition-specific questions
European rare disease database
Genetic and Rare Diseases Info Center
AI-Generated Content: This summary was generated using AI. Always consult with qualified healthcare providers for medical guidance.
Organizations with approved therapies for this disease
No approved therapies yet
Research is ongoing — 1 company has orphan drug designations for this disease
Kisho delivers this disease record via API, including phenotypes (HPO), genes, orphan drug designations, screening status, and PAG mapping, with version history and governance.