B-Cell Prolymphocytic Leukemia — Clinical Trials

MONDO:00194614 active·1 recruitingLast updated: Mar 16, 2026, 6:46 AM

Trial Landscape

B-Cell Prolymphocytic Leukemia has an emerging clinical trial program, driven by drug treatment and biological therapy.

Recruiting

Active Trials

By Approach

Drug Treatment4

Biological Therapy2

Procedure1

2 additional trials involve behavioral, dietary, diagnostic, or observational approaches.

By Phase

Phase 1

Phase 2

Sponsor Types

Academic/Other4

Trial Locations

United States4 trials

Trials often recruit across multiple countries, so totals exceed the trial count.

4 Trials

Phase 1Recruiting

NCT05418088

Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies

Sponsor:Sumithira Vasu

United StatesStarted: Jun 2022Est. completion: Jul 2026Updated: May 2025

Phase 2Active, Not Recruiting

NCT01589302

PCI-32765 (Ibrutinib) in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-cell Prolymphocytic Leukemia

Sponsor:Kami Maddocks, MD

United StatesStarted: May 2012Est. completion: Dec 2025Updated: Jul 2025

Phase 1Active, Not Recruiting

NCT03479268

Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

Sponsor:City of Hope Medical Center

United StatesStarted: Mar 2018Est. completion: Nov 2026Updated: Nov 2025

Phase 1Active, Not Recruiting

NCT02153580

Cellular Immunotherapy Following Chemotherapy in Treating Patients With Recurrent Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia, or B-Cell Prolymphocytic Leukemia

Sponsor:City of Hope Medical Center

United StatesStarted: Sep 2014Est. completion: Sep 2026Updated: Oct 2025

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Data sourced from ClinicalTrials.gov via Kisho's automated pipeline. Trials refreshed every 4 hours for monitored diseases.

Last sync: March 16, 2026 at 6:46 AM