BARD1-related cancer predisposition is a hereditary condition caused by variations in the BARD1 gene. These gene changes increase the risk of developing breast cancer, and research has shown a particular association with triple negative breast cancer in women. The condition is inherited in an autosomal dominant pattern, meaning that a change in just one copy of the gene can affect cancer risk. In addition to breast cancer, this condition has been linked with other tumor types, including neuroblastoma. This summary provides an overview of the genetic link and cancer risks associated with changes in the BARD1 gene.

Information about symptoms is currently limited for this condition.

BARD1-related cancer predisposition is caused by inherited changes in the BARD1 gene. These genetic changes, which are passed down in an autosomal dominant pattern, are linked to a moderate risk of developing certain cancers, including triple negative breast cancer in women and possibly neuroblastoma.