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The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival.
Biomarker and diagnostic research for bladder transitional cell carcinoma has been reported in the published literature.
76 clinical trials registered, 19 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 2 PHASE4, 11 PHASE3, 26 PHASE2. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT04878029](https://clinicaltrials.gov/study/NCT04878029) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:00 AM UTC
Cabozantinib in Combination With Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Cancer |
PHASE1 |
Emory University |
RECRUITING |
[NCT06396533](https://clinicaltrials.gov/study/NCT06396533) | Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy (INSITE) | — | Fox Chase Cancer Center | RECRUITING |
[NCT06809140](https://clinicaltrials.gov/study/NCT06809140) | Enfortumab Vedotin Plus Pembrolizumab With Selective Bladder Sparing for Treatment of Muscle-invasive Bladder Cancer | PHASE2 | Matthew Galsky | RECRUITING |
[NCT06770582](https://clinicaltrials.gov/study/NCT06770582) | Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial | PHASE2 | National Cancer Institute (NCI) | RECRUITING |
[NCT06257017](https://clinicaltrials.gov/study/NCT06257017) | Surveillance of the Genetic Signature in Circulating Tumor DNA for Guiding Adjuvant Chemotherapy in Urothelial Carcinoma | PHASE2 | Yung NA | RECRUITING |
150 publications have been identified in PubMed for bladder transitional cell carcinoma. Research spans Basic Science / Preclinical (34%), Diagnostic / Biomarker (26%), and Epidemiology / Natural History (14%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 51 | 34% |
Testing and diagnosis research | 39 | 26% |
Disease patterns and progression | 21 | 14% |
Clinical study results | 13 | 9% |
Patient case studies | 12 | 8% |
Research summaries | 10 | 7% |
Other research | 3 | 2% |
New treatment approaches | 1 | 1% |
Jan HC (2026). [PMID: 41861537](https://pubmed.ncbi.nlm.nih.gov/41861537/). *Cancer Treat Res Commun*. [Epidemiology / Natural History]
Fukuokaya W (2026). [PMID: 41513590](https://pubmed.ncbi.nlm.nih.gov/41513590/). *Cancer Med*. [Clinical Trial Publication]
Teh A (2026). [PMID: 41992979](https://pubmed.ncbi.nlm.nih.gov/41992979/). *Aust Vet J*. [Case Report / Case Series]
Tornesello ML (2026). [PMID: 41878440](https://pubmed.ncbi.nlm.nih.gov/41878440/). *Front Immunol*. [Epidemiology / Natural History]
Han Y (2026). [PMID: 42159673](https://pubmed.ncbi.nlm.nih.gov/42159673/). *Abdom Radiol (NY)*. [Diagnostic / Biomarker]
He Q (2026). [PMID: 41981218](https://pubmed.ncbi.nlm.nih.gov/41981218/). *NPJ Precis Oncol*. [Diagnostic / Biomarker]
Hsieh YC (2026). [PMID: 41639036](https://pubmed.ncbi.nlm.nih.gov/41639036/). *Appl Immunohistochem Mol Morphol*. [Diagnostic / Biomarker]
Qiu R (2026). [PMID: 42164352](https://pubmed.ncbi.nlm.nih.gov/42164352/). *Transl Androl Urol*. [Diagnostic / Biomarker]
Porcelli G (2026). [PMID: 41872334](https://pubmed.ncbi.nlm.nih.gov/41872334/). *BJC Rep*. [Basic Science / Preclinical]
Cheng L (2026). [PMID: 42138113](https://pubmed.ncbi.nlm.nih.gov/42138113/). *Am J Surg Pathol*. [Epidemiology / Natural History]