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renal pelvis/ureter urothelial carcinoma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

renal pelvis/ureter urothelial carcinoma

MONDO:0020654

Also known as:TCC of renal pelvis and ureterTCC of the renal pelvis and ureterUTUC

Find Clinical TrialsTrials

Overview

A transitional cell carcinoma that arises from the renal pelvis and ureter.

TreatmentsNo approved treatments · 1 in pipeline

Clinical Trials9 registered · 4 recruiting

Diagnosis

Biomarker and diagnostic research for renal pelvis/ureter urothelial carcinoma has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for renal pelvis/ureter urothelial carcinoma. An additional 1 compound holds orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for renal pelvis/ureter urothelial carcinoma, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for renal pelvis/ureter urothelial carcinoma. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

9 clinical trials registered, 4 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE4, 2 PHASE3, 4 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06774131](https://clinicaltrials.gov/study/NCT06774131)

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 8:14 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:598216

Questions for Your Care Team

→Are any of the 9 active clinical trials a good fit for my situation?
→What is the current development status of gemcitabine, and when might it become available?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Disease patterns and progression	16	31%
Patient case studies	15	29%
Research summaries	12	23%
Testing and diagnosis research	6	12%
Clinical study results	2	4%
Laboratory research	1	2%

Kisho

renal pelvis/ureter urothelial carcinoma

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Venous invasion in upper tract urothelial carcinoma: Diagnostic features and oncologic outcomes.

renal pelvis/ureter urothelial carcinoma

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Venous invasion in upper tract urothelial carcinoma: Diagnostic features and oncologic outcomes.