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A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.
Estimated prevalence: 1-9 in 100,000 (Uncommon).
13 clinical trials registered, 8 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and medical devices. Pipeline includes 1 PHASE3, 3 PHASE2, 7 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07328607](https://clinicaltrials.gov/study/NCT07328607) |
Data assembled from 4 of 12 sources · Last updated Sep 21, 2026, 4:53 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Outcomes After Laparoscopic Versus Open Pancreaticoduodenectomy |
NA |
Minia University |
RECRUITING |
[NCT05780684](https://clinicaltrials.gov/study/NCT05780684) | Individualized Dose Escalation of 5-FU for Gastrointestinal Cancer | NA | Dartmouth-Hitchcock Medical Center | RECRUITING |
[NCT04907643](https://clinicaltrials.gov/study/NCT04907643) | Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes | NA | Cedars-Sinai Medical Center | RECRUITING |
[NCT07283939](https://clinicaltrials.gov/study/NCT07283939) | Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays | NA | Alliance for Clinical Trials in Oncology | RECRUITING |
[NCT07081360](https://clinicaltrials.gov/study/NCT07081360) | Neoadjuvant vs Upfront Surgery for Resectable Pancreatic Cancer and Periampullary Cancer | PHASE3 | Minia University | RECRUITING |
33 publications have been identified in PubMed for carcinoma of the ampulla of vater. Research spans Case Report / Case Series (30%), Clinical Trial Publication (24%), and Epidemiology / Natural History (18%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 10 | 30% |
Clinical study results | 8 | 24% |
Disease patterns and progression | 6 | 18% |
Research summaries | 5 | 15% |
Laboratory research | 3 | 9% |
New treatment approaches | 1 | 3% |
Gong JI (2026). [PMID: 41669727](https://pubmed.ncbi.nlm.nih.gov/41669727/). *Journal of the Korean Society of Radiology*. [Case Report / Case Series]
Imamura H (2026). [PMID: 41617443](https://pubmed.ncbi.nlm.nih.gov/41617443/). *Anticancer research*. [Clinical Trial Publication]
Bousson J (2026). [PMID: 41745642](https://pubmed.ncbi.nlm.nih.gov/41745642/). *Acta gastro-enterologica Belgica*. [Review / Meta-Analysis]
Kagaya T (2026). [PMID: 37213167](https://pubmed.ncbi.nlm.nih.gov/37213167/). *The American surgeon*. [Case Report / Case Series]
Suzuki Y (2025). [PMID: 40705162](https://pubmed.ncbi.nlm.nih.gov/40705162/). *International journal of clinical oncology*. [Clinical Trial Publication]
Jeong JH (2025). [PMID: 40688264](https://pubmed.ncbi.nlm.nih.gov/40688264/). *Annals of surgical treatment and research*. [Review / Meta-Analysis]
Lee CH (2025). [PMID: 41244132](https://pubmed.ncbi.nlm.nih.gov/41244132/). *American journal of cancer research*. [Basic Science / Preclinical]
Shamohammadi M (2025). [PMID: 40694921](https://pubmed.ncbi.nlm.nih.gov/40694921/). *International journal of surgery case reports*. [Case Report / Case Series]
Andrianto A (2025). [PMID: 40391126](https://pubmed.ncbi.nlm.nih.gov/40391126/). *Cancer management and research*. [Epidemiology / Natural History]
Muíño Domínguez D (2025). [PMID: 38967269](https://pubmed.ncbi.nlm.nih.gov/38967269/). *Revista espanola de enfermedades digestivas*. [Case Report / Case Series]