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A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas.
Biomarker and diagnostic research for digestive system neuroendocrine tumor, grade 1/2 has been reported in the published literature.
39 clinical trials registered, 7 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and medical devices. Pipeline includes 2 PHASE4, 7 PHASE3, 9 PHASE2. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07165132](https://clinicaltrials.gov/study/NCT07165132) |
Data assembled from 3 of 12 sources · Last updated Nov 3, 2026, 10:09 PM UTC
Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs. |
PHASE1 |
RayzeBio, Inc. |
RECRUITING |
[NCT06356467](https://clinicaltrials.gov/study/NCT06356467) | Influence of Tumour and Patient's Related Factors on the Response to Medical Treatments in Well Differentiated GEP-NENs | — | IRCCS San Raffaele | RECRUITING |
[NCT04086485](https://clinicaltrials.gov/study/NCT04086485) | Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET) | PHASE1 | National Cancer Institute (NCI) | RECRUITING |
[NCT05701241](https://clinicaltrials.gov/study/NCT05701241) | Continuing Somatostatin Analogues Upon Progression in Neuroendocrine Tumour pAtients | PHASE4 | University Hospital, Antwerp | RECRUITING |
[NCT05636618](https://clinicaltrials.gov/study/NCT05636618) | Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Tumors | PHASE1 | Perspective Therapeutics | RECRUITING |
148 publications have been identified in PubMed for digestive system neuroendocrine tumor, grade 1/2. Research spans Review / Meta-Analysis (26%), Clinical Trial Publication (25%), and Epidemiology / Natural History (16%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 39 | 26% |
Clinical study results | 37 | 25% |
Disease patterns and progression | 24 | 16% |
Testing and diagnosis research | 23 | 16% |
Laboratory research | 14 | 9% |
New treatment approaches | 6 | 4% |
Other research | 4 | 3% |
Patient case studies | 1 | 1% |
Asmar C (2026). [PMID: 41547118](https://pubmed.ncbi.nlm.nih.gov/41547118/). *Cancer epidemiology*. [Clinical Trial Publication]
Zheng Q (2026). [PMID: 41766905](https://pubmed.ncbi.nlm.nih.gov/41766905/). *Front Immunol*. [Review / Meta-Analysis]
Fazio N (2026). [PMID: 41063652](https://pubmed.ncbi.nlm.nih.gov/41063652/). *Endocrine reviews*. [Basic Science / Preclinical]
Aggarwal P (2026). [PMID: 42080614](https://pubmed.ncbi.nlm.nih.gov/42080614/). *Clin Nucl Med*. [Gene Therapy / Novel Therapeutics]
Merola E (2026). [PMID: 41371459](https://pubmed.ncbi.nlm.nih.gov/41371459/). *Critical reviews in oncology/hematology*. [Epidemiology / Natural History]
Pu T (2026). [PMID: 41526627](https://pubmed.ncbi.nlm.nih.gov/41526627/). *Ann Surg Oncol*. [Clinical Trial Publication]
Ergenç M (2026). [PMID: 41998800](https://pubmed.ncbi.nlm.nih.gov/41998800/). *Cancer Control*. [Diagnostic / Biomarker]
Benevento E (2026). [PMID: 41599893](https://pubmed.ncbi.nlm.nih.gov/41599893/). *Nutrients*. [Epidemiology / Natural History]
Kim BJ (2026). [PMID: 41502317](https://pubmed.ncbi.nlm.nih.gov/41502317/). *J Gastroenterol Hepatol*. [Review / Meta-Analysis]
Perez K (2026). [PMID: 40344544](https://pubmed.ncbi.nlm.nih.gov/40344544/). *JCO oncology practice*. [Review / Meta-Analysis]