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A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas.
Biomarker and diagnostic research for digestive system neuroendocrine tumor, grade 1/2 has been reported in the published literature.
39 clinical trials registered, 12 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and medical devices. Pipeline includes 2 PHASE4, 7 PHASE3, 9 PHASE2. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07165132](https://clinicaltrials.gov/study/NCT07165132) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 1:56 PM UTC
Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs. |
PHASE1 |
RayzeBio, Inc. |
RECRUITING |
[NCT05773274](https://clinicaltrials.gov/study/NCT05773274) | Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial | PHASE2 | National Cancer Institute (NCI) | RECRUITING |
[NCT06784752](https://clinicaltrials.gov/study/NCT06784752) | Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET | PHASE3 | Novartis Pharmaceuticals | RECRUITING |
[NCT04086485](https://clinicaltrials.gov/study/NCT04086485) | Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET) | PHASE1 | National Cancer Institute (NCI) | RECRUITING |
[NCT05196087](https://clinicaltrials.gov/study/NCT05196087) | Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!) | — | University Health Network, Toronto | RECRUITING |
148 publications have been identified in PubMed for digestive system neuroendocrine tumor, grade 1/2. Research spans Review / Meta-Analysis (26%), Clinical Trial Publication (25%), and Epidemiology / Natural History (16%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 39 | 26% |
Clinical study results | 37 | 25% |
Disease patterns and progression | 24 | 16% |
Testing and diagnosis research | 23 | 16% |
Laboratory research | 14 | 9% |
New treatment approaches | 6 | 4% |
Other research | 4 | 3% |
Patient case studies | 1 | 1% |
Asmar C (2026). [PMID: 41547118](https://pubmed.ncbi.nlm.nih.gov/41547118/). *Cancer epidemiology*. [Clinical Trial Publication]
Zheng Q (2026). [PMID: 41766905](https://pubmed.ncbi.nlm.nih.gov/41766905/). *Front Immunol*. [Review / Meta-Analysis]
Fazio N (2026). [PMID: 41063652](https://pubmed.ncbi.nlm.nih.gov/41063652/). *Endocrine reviews*. [Basic Science / Preclinical]
Aggarwal P (2026). [PMID: 42080614](https://pubmed.ncbi.nlm.nih.gov/42080614/). *Clin Nucl Med*. [Gene Therapy / Novel Therapeutics]
Merola E (2026). [PMID: 41371459](https://pubmed.ncbi.nlm.nih.gov/41371459/). *Critical reviews in oncology/hematology*. [Epidemiology / Natural History]
Pu T (2026). [PMID: 41526627](https://pubmed.ncbi.nlm.nih.gov/41526627/). *Ann Surg Oncol*. [Clinical Trial Publication]
Ergenç M (2026). [PMID: 41998800](https://pubmed.ncbi.nlm.nih.gov/41998800/). *Cancer Control*. [Diagnostic / Biomarker]
Benevento E (2026). [PMID: 41599893](https://pubmed.ncbi.nlm.nih.gov/41599893/). *Nutrients*. [Epidemiology / Natural History]
Kim BJ (2026). [PMID: 41502317](https://pubmed.ncbi.nlm.nih.gov/41502317/). *J Gastroenterol Hepatol*. [Review / Meta-Analysis]
Perez K (2026). [PMID: 40344544](https://pubmed.ncbi.nlm.nih.gov/40344544/). *JCO oncology practice*. [Review / Meta-Analysis]