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digestive system neuroendocrine neoplasm - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

digestive system neuroendocrine neoplasm

MONDO:0024503

Also known as:alimentary part of gastrointestinal system NETalimentary part of gastrointestinal system neuroendocrine neoplasmalimentary part of gastrointestinal system neuroendocrine tumor

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Overview

A neoplasm with neuroendocrine differentiation arising from the digestive system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas).

Clinical Trials9 registered

Diagnosis

Biomarker and diagnostic research for digestive system neuroendocrine neoplasm has been reported in the published literature.

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:55 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:100092

GARD

Genetic and Rare Diseases Info Center

GARD:2437

Questions for Your Care Team

→Are any of the 9 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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9 clinical trials registered. Interventions under study include drug therapy, procedural interventions, and other interventions. Pipeline includes 1 PHASE4, 1 PHASE3, 3 PHASE2. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07150546](https://clinicaltrials.gov/study/NCT07150546)	Combination External Radiation and PRRT for Large GI Neuroendocrine Tumors.	PHASE1	Emory University	UNKNOWN
[NCT04234568](https://clinicaltrials.gov/study/NCT04234568)	Testing the Addition of an Anti-cancer Drug, Triapine, to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Neuroendocrine Tumors	PHASE1	National Cancer Institute (NCI)	UNKNOWN
[NCT03375320](https://clinicaltrials.gov/study/NCT03375320)	Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors	PHASE3	National Cancer Institute (NCI)	UNKNOWN
[NCT03891784](https://clinicaltrials.gov/study/NCT03891784)	Abemaciclib in Treating Patients With Advanced, Refractory, and Unresectable Digestive System Neuroendocrine Tumors	PHASE2	University of Washington	ACTIVE_NOT_RECRUITING
[NCT05262556](https://clinicaltrials.gov/study/NCT05262556)	NP-101 (TQ Formula) With Nivolumab and Ipilimumab in Advanced or Metastatic Extra-pulmonary Neuroendocrine Carcinomas	PHASE1	Amr Mohamed MD	UNKNOWN

202 publications have been identified in PubMed for digestive system neuroendocrine neoplasm. Research spans Review / Meta-Analysis (32%), Clinical Trial Publication (16%), and Basic Science / Preclinical (15%).

Research Type	Count	% of Total
Research summaries	64	32%
Clinical study results	32	16%
Laboratory research	30	15%
Testing and diagnosis research	29	14%
Disease patterns and progression	25	12%
Patient case studies	19

Recent Publications

Asmar C (2026). [PMID: 41547118](https://pubmed.ncbi.nlm.nih.gov/41547118/). *Cancer Epidemiol*. [Epidemiology / Natural History]
Lee Y (2026). [PMID: 41251953](https://pubmed.ncbi.nlm.nih.gov/41251953/). *Dig Endosc*. [Basic Science / Preclinical]
Ribeiro MB (2026). [PMID: 41983868](https://pubmed.ncbi.nlm.nih.gov/41983868/). *Arq Bras Cir Dig*. [Case Report / Case Series]
Butt BP (2026). [PMID: 41911950](https://pubmed.ncbi.nlm.nih.gov/41911950/). *J Neuroendocrinol*. [Clinical Trial Publication]
Castanho Martins M (2026). [PMID: 42007989](https://pubmed.ncbi.nlm.nih.gov/42007989/). *Endocr Relat Cancer*. [Review / Meta-Analysis]
Ammann M (2026). [PMID: 41042466](https://pubmed.ncbi.nlm.nih.gov/41042466/). *Ann Surg Oncol*. [Clinical Trial Publication]
Sciarra A (2026). [PMID: 42118458](https://pubmed.ncbi.nlm.nih.gov/42118458/). *Endocr Pathol*. [Basic Science / Preclinical]
Yogo A (2026). [PMID: 41886547](https://pubmed.ncbi.nlm.nih.gov/41886547/). *Endocr Relat Cancer*. [Basic Science / Preclinical]
Sheng YH (2026). [PMID: 41693974](https://pubmed.ncbi.nlm.nih.gov/41693974/). *World J Gastroenterol*. [Review / Meta-Analysis]
Alkaissi H (2026). [PMID: 42067273](https://pubmed.ncbi.nlm.nih.gov/42067273/). *Endocrinol Metab Clin North Am*. [Review / Meta-Analysis]

digestive system neuroendocrine neoplasm

Overview

Diagnosis

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Research Landscape

Recent Publications