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central cloudy dystrophy of François (CCDF) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

central cloudy dystrophy of François

MONDO:0009018

Also known as:CCDFcentral cloudy corneal dystrophy of Françoiscentral cloudy dystrophy of Francois

Overview

Central cloudy dystrophy of François is a very rare form of stromal corneal dystrophy characterized by polygonal or rounded stromal opacities surrounded by clear tissue, and generally no effect on vision.

GeneticsAutosomal recessive

Clinical Presentation

Features include: Clouding of the cornea (corneal dystrophy) and Central corneal dystrophy.

Organ System	Phenotype Count	Example Features
Eyes	2	Clouding of the cornea (corneal dystrophy), Central corneal dystrophy

Explore clinical features

Diagnosis

Biomarker and diagnostic research for central cloudy dystrophy of François has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for central cloudy dystrophy of François.

17 publications have been identified in PubMed for central cloudy dystrophy of François. Research spans Review / Meta-Analysis (20%), Case Report / Case Series (20%), and Clinical Trial Publication (20%).

Research Type	Count	% of Total
Research summaries	3	20%

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 5:51 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:217600

Orphanet

European rare disease database

Orphanet:98972

GARD

Genetic and Rare Diseases Info Center

GARD:16881

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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central cloudy dystrophy of François

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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