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Abnormalities in the development of the cerebral cortex. These include malformations arising from abnormal neuronal and glial cell proliferation or apoptosis (Group I); abnormal neuronal migration (Group ii); and abnormal establishment of cortical organization (Group iii). Many inborn metabolic brain disorders affecting cns formation are often associated with cortical malformations. They are common causes of epilepsy and developmental delay.
Biomarker and diagnostic research for cerebral cortical dysplasia has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
4 clinical trials registered, 3 recruiting. Interventions under study include drug therapy, gene therapy, and procedural interventions. Pipeline includes 2 PHASE1, 1 NA. Research is sponsored by a mix of industry and academic institutions.
171 publications have been identified in PubMed for cerebral cortical dysplasia. Research spans Basic Science / Preclinical (39%), Review / Meta-Analysis (26%), and Epidemiology / Natural History (10%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 60 |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 3:05 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries | 40 | 26% |
Disease patterns and progression | 15 | 10% |
Testing and diagnosis research | 13 | 8% |
Patient case studies | 12 | 8% |
Clinical study results | 7 | 5% |
New treatment approaches | 5 | 3% |
Other research | 3 | 2% |
Betting T (2026). [PMID: 41932774](https://pubmed.ncbi.nlm.nih.gov/41932774/). *Neuroimaging Clin N Am*. [Review / Meta-Analysis]
Lai A (2026). [PMID: 41670011](https://pubmed.ncbi.nlm.nih.gov/41670011/). *Ann Neurol*. [Epidemiology / Natural History]
Gamirova RG (2026). [PMID: 42133428](https://pubmed.ncbi.nlm.nih.gov/42133428/). *Zh Nevrol Psikhiatr Im S S Korsakova*. [Review / Meta-Analysis]
Winden K (2026). [PMID: 41820375](https://pubmed.ncbi.nlm.nih.gov/41820375/). *Nat Rev Dis Primers*. [Review / Meta-Analysis]
LaVere MG (2026). [PMID: 41932778](https://pubmed.ncbi.nlm.nih.gov/41932778/). *Neuroimaging Clin N Am*. [Review / Meta-Analysis]
Burkett BJ (2026). [PMID: 41932781](https://pubmed.ncbi.nlm.nih.gov/41932781/). *Neuroimaging Clin N Am*. [Review / Meta-Analysis]
Kravutske Y (2026). [PMID: 41587495](https://pubmed.ncbi.nlm.nih.gov/41587495/). *Biomed Phys Eng Express*. [Basic Science / Preclinical]
Taussig D (2025). [PMID: 40592071](https://pubmed.ncbi.nlm.nih.gov/40592071/). *Epilepsy Behav*. [Diagnostic / Biomarker]
Russ JB (2025). [PMID: 40048696](https://pubmed.ncbi.nlm.nih.gov/40048696/). *Brain*. [Review / Meta-Analysis]
Levin F (2025). [PMID: 40713655](https://pubmed.ncbi.nlm.nih.gov/40713655/). *Alzheimers Res Ther*. [Epidemiology / Natural History]
AI-curated news mentioning cerebral cortical dysplasia
Updated Mar 15, 2026
A recent case study highlights cerebral cortical encephalitis, contributing to the understanding of this rare neurological condition. The findings may inform future research and clinical approaches to similar cases.