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A neoplastic process in the cervix characterized by morphologic features of both moderate and severe intraepithelial neoplasia.
Biomarker and diagnostic research for cervical intraepithelial neoplasia grade 2/3 has been reported in the published literature.
7 clinical trials registered, 2 recruiting. Interventions under study include other interventions, drug therapy, medical devices, and biologic therapy. Pipeline includes 2 PHASE2, 1 PHASE1, 2 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07454915](https://clinicaltrials.gov/study/NCT07454915) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 9:41 PM UTC
PVX4 for the Treatment of Human Papilloma Virus (HPV)16+ Cervical Dysplasia |
PHASE2 |
PapiVax Biotech, Inc. |
RECRUITING |
[NCT06273553](https://clinicaltrials.gov/study/NCT06273553) | A Study in Subjects With Human Papillomavirus 16 or 18 Associated Cervical Intraepithelial Neoplasia Grade 2 or 3 | PHASE1 | RinuaGene Biotechnology Co., Ltd. | UNKNOWN |
[NCT03064087](https://clinicaltrials.gov/study/NCT03064087) | Validation of Human Papillomavirus Assays and Collection Devices for Self-samples and Urine Samples | — | Marc Arbyn | ACTIVE_NOT_RECRUITING |
[NCT02149030](https://clinicaltrials.gov/study/NCT02149030) | Effectiveness of Cervical Screening in HPV Vaccinated Women | NA | Tampere University | ACTIVE_NOT_RECRUITING |
[NCT04755517](https://clinicaltrials.gov/study/NCT04755517) | Effectiveness of Cervical Screening in Unvaccinated, Herd Effect Protected Women (HPV400) | NA | Tampere University Hospital | ENROLLING_BY_INVITATION |
56 publications have been identified in PubMed for cervical intraepithelial neoplasia grade 2/3. Research spans Diagnostic / Biomarker (29%), Clinical Trial Publication (29%), and Epidemiology / Natural History (20%).
Research Type | Count | % of Total |
|---|---|---|
Testing and diagnosis research | 16 | 29% |
Clinical study results | 16 | 29% |
Disease patterns and progression | 11 | 20% |
Research summaries | 5 | 9% |
Laboratory research | 5 | 9% |
Patient case studies | 2 | 4% |
Other research | 1 | 2% |
Fallah PN (2026). [PMID: 40399211](https://pubmed.ncbi.nlm.nih.gov/40399211/). *Int J Gynecol Cancer*. [Clinical Trial Publication]
Kroon KR (2026). [PMID: 41607005](https://pubmed.ncbi.nlm.nih.gov/41607005/). *Int J Cancer*. [Diagnostic / Biomarker]
Contreras Garduño S (2026). [PMID: 41384723](https://pubmed.ncbi.nlm.nih.gov/41384723/). *Cancer Epidemiol Biomarkers Prev*. [Basic Science / Preclinical]
Rothnie K (2026). [PMID: 42000375](https://pubmed.ncbi.nlm.nih.gov/42000375/). *Gynecol Oncol*. [Diagnostic / Biomarker]
Soltani LF (2026). [PMID: 41698781](https://pubmed.ncbi.nlm.nih.gov/41698781/). *J Am Board Fam Med*. [Diagnostic / Biomarker]
Li P (2026). [PMID: 41629932](https://pubmed.ncbi.nlm.nih.gov/41629932/). *BMC Womens Health*. [Diagnostic / Biomarker]
Chibwesha CJ (2026). [PMID: 41780745](https://pubmed.ncbi.nlm.nih.gov/41780745/). *Contemporary clinical trials*. [Epidemiology / Natural History]
Teodoro NS (2026). [PMID: 41891028](https://pubmed.ncbi.nlm.nih.gov/41891028/). *medRxiv*. [Clinical Trial Publication]
Tian X (2026). [PMID: 41638692](https://pubmed.ncbi.nlm.nih.gov/41638692/). *BMJ (Clinical research ed.)*. [Other]
Anton ET (2026). [PMID: 41682842](https://pubmed.ncbi.nlm.nih.gov/41682842/). *J Clin Med*. [Review / Meta-Analysis]
AI-curated news mentioning cervical intraepithelial neoplasia grade 2/3
Updated Feb 6, 2026
A rare case report highlights the association of HPV-16 with hematocervix and hematometra, leading to cervical intraepithelial neoplasia (CIN). This study contributes to the understanding of HPV's role in rare gynecological conditions.