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male infertility due to globozoospermia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

male infertility due to globozoospermia

MONDO:0015746

Also known as:Male infertility due to round-headed spermatozoaround-headed sperm syndromeglobozoospermia

Overview

Male infertility due to globozoospermia is a male infertility due to sperm disorder characterized by the presence, in sperm, of a large majority of round-headed spermatozoa that lack the acrosome and have an aberrant nuclear membrane and midpiece defects. The acrosomeless spermatozoa is not able to penetrate the zona pellucida and thus fertilization failures, even with intracytoplasmic spem injection, are frequent.

Diagnosis

Biomarker and diagnostic research for male infertility due to globozoospermia has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for male infertility due to globozoospermia.

143 publications have been identified in PubMed for male infertility due to globozoospermia. Research spans Basic Science / Preclinical (43%), Epidemiology / Natural History (15%), and Case Report / Case Series (13%).

Research Type	Count	% of Total
Laboratory research	62	43%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 7:11 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:171709

GARD

Genetic and Rare Diseases Info Center

GARD:12502

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male infertility due to globozoospermia

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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